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Chemical Structure : UNC0638
CAS No.: 1255580-76-7
Catalog No.: PC-44291Not For Human Use, Lab Use Only.
UNC0638 (UNC 0638) is a potent, selective, substrate-competitive inhibitor of G9a (EHMT2) and GLP (EHMT1) with IC50 of <15 nM and 19 nM in SAHH-coupled assays, respectively,
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $178 | In stock | |
| 50 mg | $288 | In stock | |
| 100 mg | Get quote |
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UNC0638 (UNC 0638) is a potent, selective, substrate-competitive inhibitor of G9a (EHMT2) and GLP (EHMT1) with IC50 of <15 nM and 19 nM in SAHH-coupled assays, respectively,
UNC0638 shows very weak activity against JmjD2E and DNMT1.
UNC0638 is inactive against EZH2, SETD7, DOT1L and SETD8.
UNC0638 reduces the clonogenicity of MCF7 cells and the abundance of H3K9me2.
| M.Wt | 509.7265 | |
| Formula | C30H47N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
4-Quinazolinamine, 2-cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]- |
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1. Vedadi M, et al. Nat Chem Biol. 2011 Jul 10;7(8):566-74.
2. Yu H, et al. Cell Death Dis. 2013 Feb 21;4:e506.
3. Renneville A, et al. Blood. 2015 Oct 15;126(16):1930-9.
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