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SGC2085

Chemical Structure : SGC2085

CAS No.: 1821908-48-8

SGC2085 (SGC-2085, SGC 2085)

Catalog No.: PC-42198Not For Human Use, Lab Use Only.

SGC2085 is a potent, selective protein arginine methyltransferase PRMT4 (CARM1) inhibitor with IC50 of 50 nM, displays >100-fold selectivity over other PRMTs (PRMT6 IC50=5.3 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SGC2085 is a potent, selective protein arginine methyltransferase PRMT4 (CARM1) inhibitor with IC50 of 50 nM, displays >100-fold selectivity over other PRMTs (PRMT6 IC50=5.3 uM).
SGC2085 also shows complete selectivity against a panel of 21 human protein methyltransferases.

Physicochemical Properties

M.Wt 312.4061
Formula C19H24N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 32 mg/mL

Chemical Name/SMILES

Propanamide, 2-amino-N-[[4-(3,5-dimethylphenoxy)-3-methylphenyl]methyl]-, (2S)-

References

1. Ferreira de Freitas R, et al. J Med Chem. 2016 Jul 28;59(14):6838-47.

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