| Cat. No. |
Product Name |
Information |
| PC-42922 |
MM-102
MLL1/WDR5 inhibitor
|
MM-102 is a high-affinity, small-molecule peptidomimetic inhibitor of MLL1/WDR5 protein-protein interaction with Ki of 2.4 nM. |
| PC-45489 |
PFI-2 hydrochloride
SETD7 inhibitor
|
PFI-2 ((R)-PFI-2) hydrochloride is a first-in-class, potent and selective inhibitor of SETD7 methyltransferase with Ki app/IC50 of 0.33/2 nM, respectively. |
| PC-45488 |
PFI-2
SETD7 inhibitor
|
PFI-2 ((R)-PFI-2) is a first-in-class, potent and selective inhibitor of SETD7 methyltransferase with Ki app/IC50 of 0.33/2 nM, respectively. |
| PC-27334 |
IGF2BP3-IN-2
IGF2BP3 inhibitor
|
IGF2BP3-IN-2 is a potent, selective small molecule inhibitor of RNA m6A reader insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) with IC50 of 0.12 uM in cellular thermal shift assay (CETSA). |
| PC-27333 |
I3IN-122
IGF2BP3 inhibitor
|
I3IN-122 (IGF2BP3-IN-1) is a small molecule inhibitor of RNA m6A reader insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3). |
| PC-27203 |
TCIP3
p300/CBP-BCL-6 KAT-TCIP
|
TCIP3 is a cell-permeable lysine acetyltransferase TCIP (KAT-TCIP) and bivalent molecular glue degrader that binds dually to p300/CBP and BCL6, redirects p300/CBP to BCL6, exhibits potent anti-proliferative effect in DLBCL cells. |
| PC-27108 |
EZH2 inhibitor C36
EZH2-PRC2 inhibitor
|
EZH2 inhibitor C36 is a potent, selective and allosteric EZH2-PRC2 inhibitor with IC50 of 2.27 nM in AlphaLisa assays, inhibits both the basal and activated forms of the PRC2 complex containing EZH2, but not EZH1, in a SAM-noncompetitive manner. |
| PC-26996 |
TNG917
EHMT1/2 inhibitor
|
TNG917 is a potent, selective, histone substrate-competitive, orally active dual inhibitor of EHMT1/2, shows high selectivity over other methyltransferases. |
| PC-26788 |
AZD3470
PRMT5 inhibitor
|
AZD3470 (AZD-3470) is a potent, seleective MTA-cooperative PRMT5 inhibitor, targets MTAP deficient advanced/metastatic cancer cells. |
| PC-26595 |
SCR-6920
PRMT5 inhibitor
|
SCR-6920 is a potent and selective, oral PRMT5 inhibitor with IC50 of 1.48 nM. |
| PC-26589 |
UNC7242
PHF1/PHF19 inhibitor
|
UNC7242 is a small molecule antagonist of PRC2 components PHF1 and PHF19 with ITC Kd of 1.13 uM and 0.64 uM, displaces recombinant or endogenous PHF1 or 19 from nucleosomes. |
| PC-26565 |
GD433
NTMT1 inhibitor
|
GD433 is a potent, selective and substrate competitive inhibitor of N-terminal methyltransferase 1 (NTMT1) with IC50 of 27 nM. |
