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Cat. No. Product Name Information
PC-21040

EPZ033294

SMYD2 inhibitor

EPZ033294 is a potent, selective inhibitor of SMYD2 with biochemical IC50 of 3.9 nM, and function of cellular methylation IC50 of 29 nM.
PC-21039

EPZ028862

SMYD3 inhibitor

EPZ028862 is a potent, selective inhibitor of SMYD3 with biochemical IC50 of 1.8 nM, and function of cellular methylation IC50 of 32 nM.
PC-21013

EML1219

PRMT9 inhibitor

EML1219 is a selective small molecule inhibitor of protein arginine methyltransferase isoform PRMT9 with IC50 of 0.2 uM.
PC-20906

EPIC-0307

PRADX-EZH2 inhibitor

EPIC-0307 is a selective small-molecule inhibitor of PRADX-EZH2 interaction, inhibits GBM cell lines with IC50 of 12.13-17.69 uM, enhances temozolomide (TMZ) sensitivity to glioblastoma.
PC-20858

BBDDL2059

EZH2 inhibitor

BBDDL2059 (BBDDL 2059) is a potent, selective and covalent inhibitor of EZH2 with IC50 of 1.5 nM (EZH2-Y641F), targeting the Cys663 of EZH2.
PC-20857

CPI-1328

EZH2 inhibitor

CPI-1328 is a highly potent, selective EZH2 inhibitor with sub-pM binding affinitiy (Ki=63 fM).
PC-20832

SETDB1 activator (R,R)-59

SETDB1 activator

(R,R)-59 is a small-molecule ligand activator for methyltransferase SETDB1 Triple Tudor Domain (3TD reader domain) with binding IC50 of 1.2 uM in TR-FRET assays, specifically promotes in vitro SETDB1-mediated methylation of lysine 64 of protein kinase Akt1.
PC-20564

M-808

menin-MLL inhibitor

M-808 (M808) is a highly potent, selective and covalent inhibitor of menin-MLL interaction with binding IC50 of 2.6 nM, forms a covalent bond with Cys329 in menin.
PC-20514

Pociredir

PRC2 inhibitor

Pociredir (FTX-6058) is an oral, allosteric polycomb repressive complex 2 (PRC2) inhibitor.
PC-49814

SMYD3 inhibitor 49

SMYD3 inhibitor

SMYD3 inhibitor 49 is a potent and selective SMYD3 inhibitor with IC50 of 6.3 and 44 nM in biochemical and cellular MEKK2me assays, respectively.

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