| Cat. No. |
Product Name |
Information |
| PC-21491 |
DP308
53BP1 inhibitor
|
DP308 is a novel and effective 53BP1 tandem Tudor domain (TTD) inhibitor, disrupts the binding between 53BP1 and H4K20me2 peptide with IC50 of 1.69 uM. |
| PC-21490 |
UNC7648
53BP1 inhibitor
|
UNC7648 is a small molecule inhibitor of the methyl-lysine reader p53 binding protein 1 (53BP1) tandem Tudor domain (TTD) with TR-FRET IC50 of 8.6 uM. |
| PC-21489 |
UNC9512
53BP1 inhibitor
|
UNC9512 is a selective methyl-lysine reader p53 binding protein 1 (53BP1) antagonist, binds the 53BP1 tandem Tudor domain (TTD) with TR-FRET IC50 of 0.46 uM, and SPR/ITC Kd vfalues of 0.17/0.41 uM respectively. |
| PC-21345 |
iPRMT1
PRMT1 inhibitor
|
iPRMT1 is a potent and selective PRMT1 inhibitor with IC50 of 270 nM, shows good selectivity over other PRMTs. |
| PC-21273 |
C220
PRMT5 inhibitor
|
C220 (PRMT5 inhibitor C220) is a highly potent, selective and SAM cpmpetitive inhibitor of protein arginine methyltransferase 5 (PRMT5) with IC50 of 2.4 nM. |
| PC-21272 |
PRT543
PRMT5 inhibitor
|
PRT543 is a highly potent, selective and SAM cpmpetitive inhibitor of protein arginine methyltransferase 5 (PRMT5) with IC50 of 10.8 nM. |
| PC-21040 |
EPZ033294
SMYD2 inhibitor
|
EPZ033294 is a potent, selective inhibitor of SMYD2 with biochemical IC50 of 3.9 nM, and function of cellular methylation IC50 of 29 nM. |
| PC-21039 |
EPZ028862
SMYD3 inhibitor
|
EPZ028862 is a potent, selective inhibitor of SMYD3 with biochemical IC50 of 1.8 nM, and function of cellular methylation IC50 of 32 nM. |
| PC-21013 |
EML1219
PRMT9 inhibitor
|
EML1219 is a selective small molecule inhibitor of protein arginine methyltransferase isoform PRMT9 with IC50 of 0.2 uM. |
| PC-20906 |
EPIC-0307
PRADX-EZH2 inhibitor
|
EPIC-0307 is a selective small-molecule inhibitor of PRADX-EZH2 interaction, inhibits GBM cell lines with IC50 of 12.13-17.69 uM, enhances temozolomide (TMZ) sensitivity to glioblastoma. |
| PC-20858 |
BBDDL2059
EZH2 inhibitor
|
BBDDL2059 (BBDDL 2059) is a potent, selective and covalent inhibitor of EZH2 with IC50 of 1.5 nM (EZH2-Y641F), targeting the Cys663 of EZH2. |
| PC-20857 |
CPI-1328
EZH2 inhibitor
|
CPI-1328 is a highly potent, selective EZH2 inhibitor with sub-pM binding affinitiy (Ki=63 fM). |
