YD1342

Chemical Structure : YD1342

Catalog No.: PC-23238Not For Human Use, Lab Use Only.

YD1342 is the in-vivo active prodrug of YD1130, a potent, selective PRMT4 inhibitor with IC50 of <1 nM, 1000-fold selectivity for PRMT4 (IC50 < 0.5 nM).

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Biological Activity

YD1342 is the in-vivo active prodrug of YD1130, a potent, selective PRMT4 inhibitor with IC50 of <1 nM, 1000-fold selectivity for PRMT4 (IC50 < 0.5 nM).
YD1342 exhibited potent inhibition on cellular substrate methylation, breast cancer cell colony formation, and tumor growth in the animal model.

Physicochemical Properties

M.Wt	727.68
Formula	C33H39BrN6O6S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-((((2S,3R,4R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)thio)ethyl)-N-(3-bromobenzyl)-3-methyl-3-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanamide

References

1. Deng Y, et al. J Med Chem. 2024 Oct 3. doi: 10.1021/acs.jmedchem.4c01041.

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YD1342

Biological Activity

Physicochemical Properties

References

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