| Cat. No. |
Product Name |
Information |
| PC-25273 |
UNC0646
G9a inhibitor
|
UNC0646 (UNC 0646) is a potent, selective and cell-active inhibitor of G9a methyltransferase with IC50 of 6 nM in SAHH-coupled assays, reduces H3K9me2 levels in MDA-MB-231 cells with IC50 of 26 nM. |
| PC-25272 |
UNC0631
G9a inhibitor
|
UNC0631 (UNC 0631) is a potent, selective and cell-active inhibitor of G9a methyltransferase with IC50 of 4 nM in SAHH-coupled assays, reduces H3K9me2 levels in MDA-MB-231 cells with IC50 of 25 nM. |
| PC-25006 |
SHR2554
EZH2 inhibitor
|
Zeprumetostat (SHR2554) is a potent, highly selective EZH2 inhibitor, specifically inhibits both wild-type (IC50=0.87 nM) and mutant (EZH2(Y641F), IC50=2.68 nM) EZH2 methyltransferase activity with similar potencies. |
| PC-24896 |
KMT9 inhibitor 7b
KMT9 inhibitor
|
KMT9 inhibitor 7b is a potent and selective lysine methyltransferase 9 (KMT9) inhibitor with Kd of 10 nM. |
| PC-24714 |
PRMT5 inhibitor 16-19F
PRMT5-MTA inhibitor
|
PRMT5 inhibitor 16-19F is a specific synthetic inhibitor of the PRMT5-MTA complex with SPR KD of 2.54, 0.36 and 0.15 uM against apo-PRMT5:MEP50 and SAM- and MTA-bound PRMT5:MEP50 complexes respectively, selectively inhibits MTAP-deleted cancer cell growth. |
| PC-24649 |
IGF2BP1 inhibitor A11
IGF2BP1 inhibitor
|
IGF2BP1 inhibitor A11 is a specific small molecule insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) inhibitor, binds to IGF2BP protein with KD of 2.88 nM. |
| PC-24610 |
AM-9934
PRMT5 inhibitor
|
AM-9934 is a potent, selective and MTA-cooperative PRMT5 inhibitor with IC50 of12 nM for PRMT5 methyltransferase activity and 40 nM for PRMT5:MEP50 enzymatic affinity, selectively inhibits PRMT5 in MTAP-deleted cells. |
| PC-24609 |
BCOR-PCGF1 inhibitor iBP
PRC1.1 inhibitor
|
BCOR-PCGF1 inhibitor iBP is a selective PRC1.1 inhibitor, specifically inhibits the interaction between BCOR and PCGF1 with IC50 of 12.21 uM in AlphaScreen assays, limits H2AK119ub1 activity and activates Wnt signaling pathway. |
| PC-24531 |
CG3-46
CBX2 inhibitor
|
CG3-46 is a specific nonpeptide small molecule CBX2 inhibitor, inhibits the interaction between CBX2 and H3K27me3 with IC50 of 15.4 μM and 14.6 μM in NanoBRET and NanoBiT assays, respectively. |
| PC-24527 |
HH2853
EZH1/2 inhibitor
|
HH2853 is a novel potent dual EZH1/2 inhibitor that effectively inhibit the catalytic activity of wild-type EZH2 and mutated forms (A677G, Y641F, Y641N, and Y641C) with IC50 of 3.75, 2.21, 2.65, and 2.62 nM respectively, synchronously suppresses EZH1 activity with IC50 of 9.26 nM. |
| PC-24375 |
CM112
PRMT1 degrader
|
CM112 is a potent, selective PRMT1 degrader designed by tethering adamantane to MS023 via a 5-PEG linker, has DC50 of 0.83 uM in MCF-7 cells. |
| PC-24337 |
iZMYND8-34
ZMYND8 inhibitor
|
iZMYND8-34 is a small molecule inhibitor of histone reader zinc finger MYND-type containing 8 (ZMYND8), inhibits ZMYND8 histone recognition, effectively blocks neuroendocrine prostate cancer (NEPC) development. |
