| Cat. No. |
Product Name |
Information |
| PC-73451 |
Tulmimetostat
EZH2 inhibitor
|
Tulmimetostat (CPI-0209) is a potent, selective, orally available EZH2 inhibitor with Ki of 140 fM by kinetic analyses and Ki 180 fM by thermal shift assays. |
| PC-73322 |
EZM0414
SETD2 inhibitor
|
EZM 0414 is a potent, selective and orally bioavailable inhibitor of histone methyltransferase SETD2 with biochemical IC50 of 18 nM, >10,000-fold selectivity over other HMTases. |
| PC-73122 |
MRK-740
PRDM9 inhibitor
|
MRK-740 (MRK740) is a first-in-class, potent, selective and cell-active PRDM9 inhibitor with IC50 of 80 nM. |
| PC-73099 |
SKI-73
CARM1 inhibitor
|
SKI-73 is a CARM1 chemical probe with pro-drug properties, can readily penetrate cell membranes and then be processed into two active CARM1 inhibitors. |
| PC-73067 |
BR-001
PRC2 EED inhibitor
|
BR-001 (BR001) is a potent, selective, allosteric inhibitor of EED subunit of PRC2 complex, disrupts EED-H3K27me3 interaction (IC50=4.5 nM). |
| PC-73054 |
PFI-5
SMYD2 inhibitor
|
PFI-5 a highly biochemically potent, selective, and cell-active SMYD2 chemical probe with IC50 of 8 nM. |
| PC-73027 |
SPIN1 inhibitor MS31
SPIN1 inhibitor
|
SPIN1 inhibitor MS31 (MS31) is a potent, selective, and cell-active inhibitor of methyllysine reader protein SPIN1 (spindlin 1) with IC50 of 77 nM. |
| PC-72992 |
SMYD3 inhibitor 29
SMYD3 inhibitor
|
SMYD3 inhibitor 29 is a highly potent, selective, covalent inhibitor of histone methyltransferase SMYD3 with IC50 of 1.7 nM. |
| PC-72793 |
SNDX5613
menin-MLL inhibitor
|
Revumenib (SNDX-5613) is a potent and selective inhibitor of menin-MLL binding with Ki of 0.149 nM. |
| PC-72792 |
VTP50469
menin-MLL inhibitor
|
VTP50469 (VTP 50469) is potent, selective, orally active inhibitor of Menin-MLL interaction with Ki of 104 pM. |
| PC-72717 |
NAH-C3-GPKK
NTMT1/KMT9 inhibitor
|
NAH-C3-GPKK is a potent, selective protein N-terminal methyltransferase 1 (NTMT1) bisubstrate inhibitor with Kiapp of 7 nM in endogenous proteomes. |
| PC-72716 |
Compound II757
pan-PRMT inhibitor
|
Compound II757 (II757) is a potent, cell-active pan-PRMT inhibitor with IC50 of 5-555 nM for eight PRMTs, with the highest inhibition for PRMT4 (IC50=5 nM). |
