| Cat. No. |
Product Name |
Information |
| PC-73067 |
BR-001
PRC2 EED inhibitor
|
BR-001 (BR001) is a potent, selective, allosteric inhibitor of EED subunit of PRC2 complex, disrupts EED-H3K27me3 interaction (IC50=4.5 nM). |
| PC-73054 |
PFI-5
SMYD2 inhibitor
|
PFI-5 a highly biochemically potent, selective, and cell-active SMYD2 chemical probe with IC50 of 8 nM. |
| PC-73027 |
SPIN1 inhibitor MS31
SPIN1 inhibitor
|
SPIN1 inhibitor MS31 (MS31) is a potent, selective, and cell-active inhibitor of methyllysine reader protein SPIN1 (spindlin 1) with IC50 of 77 nM. |
| PC-72992 |
SMYD3 inhibitor 29
SMYD3 inhibitor
|
SMYD3 inhibitor 29 is a highly potent, selective, covalent inhibitor of histone methyltransferase SMYD3 with IC50 of 1.7 nM. |
| PC-72793 |
SNDX5613
menin-MLL inhibitor
|
Revumenib (SNDX-5613) is a potent and selective inhibitor of menin-MLL binding with Ki of 0.149 nM. |
| PC-72792 |
VTP50469
menin-MLL inhibitor
|
VTP50469 (VTP 50469) is potent, selective, orally active inhibitor of Menin-MLL interaction with Ki of 104 pM. |
| PC-72717 |
NAH-C3-GPKK
NTMT1/KMT9 inhibitor
|
NAH-C3-GPKK is a potent, selective protein N-terminal methyltransferase 1 (NTMT1) bisubstrate inhibitor with Kiapp of 7 nM in endogenous proteomes. |
| PC-72716 |
Compound II757
pan-PRMT inhibitor
|
Compound II757 (II757) is a potent, cell-active pan-PRMT inhibitor with IC50 of 5-555 nM for eight PRMTs, with the highest inhibition for PRMT4 (IC50=5 nM). |
| PC-72640 |
SGC6870N
PRMT6 inhibitor
|
SGC6870N is the negative control of SGC-6870 (R-isomer), which is a potent, selective, cell-active PRMT6 inhibitor. |
| PC-72639 |
SGC6870
PRMT6 inhibitor
|
SGC6870 (SGC-6870 (R-isomer)) is a potent, selective, cell-active PRMT6 inhibitor with IC50 of 77 nM. |
| PC-72620 |
PF-06821497
EZH2 Y641N inhibitor
|
PF-06821497 (PF 06821497) is a potent, selective, orally bioavailable Enhancer of Zeste Homolog 2 (EZH2) inhibitor with Ki of <1 nM against Y641N mutant. |
| PC-72600 |
GSK3368715
Type I PRMT inhibitor
|
GSK3368715 (EPZ019997, GSK-3368715) is a potent, reversible and SAM uncompetitive type I PRMT inhibitor with Kiapp of 1.5 to 81 nM for PRMT1, 3, 4, 6, and 8. |
