| Cat. No. |
Product Name |
Information |
| PC-25447 |
DNMT2 inhibitor 16
DNMT2 inhibitor
|
DNMT2 inhibitor 16 is a potent, selective DNMT2 (TRDMT1) inhibitor with ITC KD of 3.04 uM, reduces m5C levels in MOLM-13 tRNA and synergizes with doxorubicin to impair cell viability, targeting a cryptic allosteric binding site. |
| PC-25345 |
SKLB-Y13
YTHDF1 inhibitor
|
SKLB-Y13 is the first, selective small-molecule inhibitor targeting of the YTHDF1 m6A-binding pocket with IC50 of 0.76 uM, has selectivity for YTHDF1 over YTH family proteins. |
| PC-25322 |
IACS-17817
NSD2 inhibitor
|
IACS-17817 is a highly potent, selective and SAM-competitive inhibitor of NSD2 (MMSET, WHSC1) with IC50 of 19.0 nM, >50-fold selective over a KMT panel including NSD1, NSD3 and SETD2. |
| PC-25321 |
IACS-17596
NSD2 inhibitor
|
IACS-17596 is a highly potent, selective and SAM-competitive inhibitor of NSD2 (MMSET, WHSC1) with IC50 of 8.8 nM, >300-fold selective over a KMT panel including NSD1, NSD3 and SETD2. |
| PC-25273 |
UNC0646
G9a inhibitor
|
UNC0646 (UNC 0646) is a potent, selective and cell-active inhibitor of G9a methyltransferase with IC50 of 6 nM in SAHH-coupled assays, reduces H3K9me2 levels in MDA-MB-231 cells with IC50 of 26 nM. |
| PC-25272 |
UNC0631
G9a inhibitor
|
UNC0631 (UNC 0631) is a potent, selective and cell-active inhibitor of G9a methyltransferase with IC50 of 4 nM in SAHH-coupled assays, reduces H3K9me2 levels in MDA-MB-231 cells with IC50 of 25 nM. |
| PC-25006 |
SHR2554
EZH2 inhibitor
|
Zeprumetostat (SHR2554) is a potent, highly selective EZH2 inhibitor, specifically inhibits both wild-type (IC50=0.87 nM) and mutant (EZH2(Y641F), IC50=2.68 nM) EZH2 methyltransferase activity with similar potencies. |
| PC-24896 |
KMT9 inhibitor 7b
KMT9 inhibitor
|
KMT9 inhibitor 7b is a potent and selective lysine methyltransferase 9 (KMT9) inhibitor with Kd of 10 nM. |
| PC-24714 |
PRMT5 inhibitor 16-19F
PRMT5-MTA inhibitor
|
PRMT5 inhibitor 16-19F is a specific synthetic inhibitor of the PRMT5-MTA complex with SPR KD of 2.54, 0.36 and 0.15 uM against apo-PRMT5:MEP50 and SAM- and MTA-bound PRMT5:MEP50 complexes respectively, selectively inhibits MTAP-deleted cancer cell growth. |
| PC-24649 |
IGF2BP1 inhibitor A11
IGF2BP1 inhibitor
|
IGF2BP1 inhibitor A11 is a specific small molecule insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) inhibitor, binds to IGF2BP protein with KD of 2.88 nM. |
| PC-24610 |
AM-9934
PRMT5 inhibitor
|
AM-9934 is a potent, selective and MTA-cooperative PRMT5 inhibitor with IC50 of12 nM for PRMT5 methyltransferase activity and 40 nM for PRMT5:MEP50 enzymatic affinity, selectively inhibits PRMT5 in MTAP-deleted cells. |
| PC-24609 |
BCOR-PCGF1 inhibitor iBP
PRC1.1 inhibitor
|
BCOR-PCGF1 inhibitor iBP is a selective PRC1.1 inhibitor, specifically inhibits the interaction between BCOR and PCGF1 with IC50 of 12.21 uM in AlphaScreen assays, limits H2AK119ub1 activity and activates Wnt signaling pathway. |
