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UNC0642

Chemical Structure : UNC0642

CAS No.: 1481677-78-4

UNC0642 (UNC-0642, UNC 0642)

Catalog No.: PC-49728Not For Human Use, Lab Use Only.

UNC0642 (UNC 0642) is a potent and selective G9a and GLP histone lysine methyltransferase inhibitor with IC50 of <2.5 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

UNC0642 (UNC 0642) is a potent and selective G9a and GLP histone lysine methyltransferase inhibitor with IC50 of <2.5 nM.
UNC0642 displays >2,000-fold selectivity for G9a and GLP over PRC2-EZH2 and >20,000-fold selectivity over other methyltransferases.
UNC0642 reduces H3K9 dimethylation levels with IC50 of <150 nM in U2OS, PC3, and PANC-1 cells, exhibits excellent potency (IC50 = 40 nM) in PANC-1 cells.
UNC0642 reduces clonogenicity in PANC-1 cells in a concentration-dependent manner while it had no effect on clonogenicity in MDA-MB-231 cells.

Physicochemical Properties

M.Wt 546.71
Formula C29H44F2N6O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(4,4-Difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine

References

1. Feng Li, et al. J Med Chem. 2013 Nov 14;56(21):8931-42.

2. Sebastian Scheer, et al. Nat Commun. 2019 Jan 3;10(1):19.

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