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Cat. No. Product Name Information
PC-70162

EML405

SPIN1 inhibitor

EML405 (EML 405) is a small-molecule inhibitor of the methyl-lysine reader protein Spindlin1 (SPIN1) with Kd of 14 uM.
PC-70161

UNC-1679

L3MBTL3 inhibitor

UNC-1679 (UNC1679) is a potent and selective small molecule chemical probe of a methyl-lysine reader protein L3MBTL3 with Ki of 0.35 uM.
PC-70114

MM-401

MLL1/WDR5 inhibitor

MM-401 is a potent inhibitor of MLL1/WDR5 protein-protein interaction with IC50 of 0.9 nM.
PC-70109

GSK-2807

GSK-2807 (GSK 2807, GSK2807) is a potent and selective, SAM-competitive inhibitor of SMYD3 with Ki of 14 nM.
PC-70108

BCI-121

SMYD3 inhibitor

BCI-121 (BCI121) is a substrate-competitive SMYD3 inhibitor that significantly inhibits SMYD3-substrate interaction and chromatin recruitment and is effective in reducing proliferation in various cancer cells types.
PC-70107

EPZ-030456

EPZ-030456 (EPZ030456) is a potent, selective SMYD3 inhibitor with biochem IC50 of 4 nM.
PC-70104

MM-589

MLL1/WDR5 inhibitor

MM-589 is a highly potent, cell-permeable inhibitor of WDR5-MLL interaction with IC50 of 0.9 nM, Ki of <1 nM.
PC-60300

MS-453

SETD8 inhibitor

MS-453 (MS453) is a potent, selective and covalent protein lysine methyltransferase SETD8 inhibitor with IC50 of 804 nM.
PC-60299

CPI-1205

Lirametostat (CPI-1205) is a highly potent, selective EZH2 inhibitor with biochemical IC50 of 2 nM, cellular EC50 of 32 nM.
PC-60263

JQEZ5

EZH2 inhibitor

JQEZ5 (JQ5, EZ005) is a novel potent, selective, SAM-competitive EZH2 inhibitor with IC50 of 80 nM (inhibition of enzymatic function of PRC2).
PC-60256

CM-579

G9a inhibitor

CM-579 (CM579) is a novel potent, selective and reversible dual inhibitor of G9a/DNMTs with IC50 of 16 nM and 32 nM for G9a and DNMT1, respectively.
PC-60255

CM-272

G9a inhibitor

CM-272 (CM272) is a novel potent, selective and reversible dual inhibitor of G9a/DNMTs with IC50 of 8 nM and 382 nM for G9a and DNMT1, respectively.

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