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Chemical Structure : Chaetocin
CAS No.: 28097-03-2
Catalog No.: PC-62758Not For Human Use, Lab Use Only.
Chaetocin is a potent, specific, SAM-competitive inhibitor of histone H3K9 methyltransferase (HMT) SU(VAR)3-9 with IC50 of 0.6 uM, no actiivty against H4 Lys20-specific HMT PRSET7 and SET7/9.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $158 | In stock | |
| 5 mg | $388 | In stock | |
| 10 mg | $598 | In stock | |
| 25 mg | Get quote |
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Chaetocin is a potent, specific, SAM-competitive inhibitor of histone H3K9 methyltransferase (HMT) SU(VAR)3-9 with IC50 of 0.6 uM, no actiivty against H4 Lys20-specific HMT PRSET7 and SET7/9.
Chaetocin inhibits the human ortholog of dSU(VAR)3-9 with IC50 of 0.8 uM, also inhibits Lys9-specific HMTs such as mouse G9a and Neurospora crassa DIM5 (IC50=2.5 and 3 uM).
Chaetocin prolongs survival and restores mitochondrial dysfunction, improves prognosis in a rat model of high salt diet-induced heart failure。
Chaetocin induces cell cycle arrest and apoptosis in melanoma cells.
| M.Wt | 696.851 | |
| Formula | C30H28N6O6S4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
O=C([C@@](N1C)(SS2)CO)N3[C@](NC4=CC=CC=C54)([H])[C@]5([C@@]6(C7=CC=CC=C7N8)[C@@]8([H])N(C9=O)[C@](C%10=O)(SS[C@]9(CO)N%10C)C6)C[C@]32C1=O |
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1. Greiner D, et al. Nat Chem Biol. 2005 Aug;1(3):143-5.
2. Vo MC, et al. Oncotarget. 2017 Jul 11;8(28):46047-46056.
3. Yang G, et al. Nat Commun. 2017 Mar 31;8:14941.
4. Ono T, et al. Sci Rep. 2017 Jan 4;7:39752.
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