EZH2-IN-3 |CAS:1377997-28-8 Probechem Biochemicals

Chemical Structure : EZH2-IN-3

EZH2-IN-3

Catalog No.: PC-62468Not For Human Use, Lab Use Only.

EZH2-IN-3 is a highly selective small molecule inhibitor of EZH2 and EZH1 with IC50 of 21/197/213 nM for wt EZH2/EZH2 Y641N/wt EZH1 respectively.

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Biological Activity

EZH2-IN-3 is a highly selective small molecule inhibitor of EZH2 and EZH1 with IC50 of 21/197/213 nM for wt EZH2/EZH2 Y641N/wt EZH1 respectively.
EZH2-IN-3 suppresses global histone H3-lysine 27 methylation and cause selective proliferation defects.

Physicochemical Properties

M.Wt	490.004
Formula	C27H28ClN5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-chloro-4-(2-cyano-3-(pyridazin-4-yl)phenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide

References

1. Garapaty-Rao S, et al. Chem Biol. 2013 Nov 21;20(11):1329-39.

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EZH2-IN-3

Biological Activity

Physicochemical Properties

References

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