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EZH2-IN-3

Chemical Structure : EZH2-IN-3

CAS No.: 1377997-28-8

EZH2-IN-3

Catalog No.: PC-62468Not For Human Use, Lab Use Only.

EZH2-IN-3 is a highly selective small molecule inhibitor of EZH2 and EZH1 with IC50 of 21/197/213 nM for wt EZH2/EZH2 Y641N/wt EZH1 respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    EZH2-IN-3 is a highly selective small molecule inhibitor of EZH2 and EZH1 with IC50 of 21/197/213 nM for wt EZH2/EZH2 Y641N/wt EZH1 respectively.
    EZH2-IN-3 suppresses global histone H3-lysine 27 methylation and cause selective proliferation defects.

    Physicochemical Properties

    M.Wt 490.004
    Formula C27H28ClN5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    3-chloro-4-(2-cyano-3-(pyridazin-4-yl)phenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide

    References

    1. Garapaty-Rao S, et al. Chem Biol. 2013 Nov 21;20(11):1329-39.

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