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Chemical Structure : M-525
Catalog No.: PC-62486Not For Human Use, Lab Use Only.
M-525 is a first-in-class, highly potent, irreversible small-molecule inhibitor of the menin-MLL interaction with binding IC50 of 3.3 nM in FP assays.
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M-525 is a first-in-class, highly potent, irreversible small-molecule inhibitor of the menin-MLL interaction with binding IC50 of 3.3 nM in FP assays.
M-525 inhibits MV4;11 (MLL fusion) and HL60 (No MLL fusion) cell growth with IC50 of 2.7 and 2,000 nM, respectively.
M-525 significantly down-regulates the expression of MEIS1, HOXA9 and HOXA11 genes in a dosedependent anner at ow nanomolar concentrations.
M-525 also effectively suppresses the expression of MEIS1 and HOX genes in the MOLM-13 cell line at 3 nM.
| M.Wt | 734.932 | |
| Formula | C39H51FN6O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Xu S, et al. Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1601-1605.
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