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Sinefungin

Chemical Structure : Sinefungin

CAS No.: 58944-73-3

Sinefungin (A 9145, RP32232)

Catalog No.: PC-62408Not For Human Use, Lab Use Only.

Sinefungin (A 9145, RP 32232) is a non-selective inhibitor of SET domain-containing methyltransferases in the study of epigenetic regulation (IC50 values range from 0.1-20 uM).

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Biological Activity

Sinefungin (A 9145, RP 32232) is a non-selective inhibitor of SET domain-containing methyltransferases in the study of epigenetic regulation (IC50 values range from 0.1-20 uM).
Sinefungin is a nucleoside structurally related to S-adenosylhomocysteine and S-adenosylmethionine that isolated from Streptomyces.
Sinefungin demonstrates high in vivo toxicity.
Sinefungin inhibits SET7/9 and ameliorates renal fibrosis by inhibiting H3K4 methylation

Physicochemical Properties

M.Wt 381.4
Formula C15H23N7O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2S,5S)-2,5-Diamino-6-((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)hexanoic acid

References

1. Tisi D, et al. ACS Chem Biol. 2016 Nov 18;11(11):3093-3105.

2. van Haren MJ, et al. Biochemistry. 2016 Sep 20;55(37):5307-15.

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