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Chemical Structure : CMP-5 hydrochloride
Catalog No.: PC-62980Not For Human Use, Lab Use Only.
CMP-5 (PRMT5-IN-5)is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival, without effect on normal B cells.
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CMP-5 (PRMT5-IN-5) hydrochloride is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival, without effect on normal B cells.
CMP-5 displays no activity against other type I (PRMT1 and PRMT4) and type II (PRMT7) enzymes.
Inhibition of PRMT5 leads to lost recruitment of a PRMT5/p65/HDAC3-repressive complex on the miR96 promoter, restored miR96 expression, and PRMT5 downregulation.
| M.Wt | 351.87 | |
| Formula | C21H22ClN3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Alinari L, et al. Blood. 2015 Apr 16;125(16):2530-43.
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