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CMP-5 hydrochloride

Chemical Structure : CMP-5 hydrochloride

CAS No.: 1030021-40-9

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CMP-5 hydrochloride (PRMT5-IN-5)

Catalog No.: PC-62980Not For Human Use, Lab Use Only.

CMP-5 (PRMT5-IN-5)is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival, without effect on normal B cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CMP-5 (PRMT5-IN-5) hydrochloride is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival, without effect on normal B cells.
    CMP-5 displays no activity against other type I (PRMT1 and PRMT4) and type II (PRMT7) enzymes.
    Inhibition of PRMT5 leads to lost recruitment of a PRMT5/p65/HDAC3-repressive complex on the miR96 promoter, restored miR96 expression, and PRMT5 downregulation.

    Physicochemical Properties

    M.Wt 351.87
    Formula C21H22ClN3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-pyridinylmethyl)methanamine hydrochloride

    References

    1. Alinari L, et al. Blood. 2015 Apr 16;125(16):2530-43.

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