MI-2-2 is a potent inhibitor of the menin-MLL interaction that binds to menin with low nanomolar affinity (Kd=22 nM).
MI-2-2 inhibits the interaction of menin with MLL-AF9 in HEK293 cells in a dose-dependent manner with 4-fold potentcy improvement over MI-2.
MI-2-2 suppresses growth of MLL-AF9–transformed BMCs.
MI-2-2 causes MV4:11 cells growth inhibition of with GI50 of 3 uM.
