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Chemical Structure : MI-2-2
CAS No.: 1454920-20-7
Catalog No.: PC-62485Not For Human Use, Lab Use Only.
MI-2-2 is a potent inhibitor of the menin-MLL interaction that binds to menin with low nanomolar affinity (Kd=22 nM).
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MI-2-2 is a potent inhibitor of the menin-MLL interaction that binds to menin with low nanomolar affinity (Kd=22 nM).
MI-2-2 inhibits the interaction of menin with MLL-AF9 in HEK293 cells in a dose-dependent manner with 4-fold potentcy improvement over MI-2.
MI-2-2 suppresses growth of MLL-AF9–transformed BMCs.
MI-2-2 causes MV4:11 cells growth inhibition of with GI50 of 3 uM.
| M.Wt | 415.497 | |
| Formula | C17H20F3N5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(4-(5,5-Dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidine |
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1. Arkin MR, et al. Chem Biol. 2014 Sep 18;21(9):1102-14.
2. Shi A, et al. Blood. 2012 Nov 29;120(23):4461-9.
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