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Chemical Structure : EBI-2511
CAS No.: 2098546-05-3
Catalog No.: PC-62526Not For Human Use, Lab Use Only.
EBI-2511 is a highly potent and orally active EZH2 inhibitor with IC50 of 4 nM against mutant EZH2 A677G.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $428 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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EBI-2511 is a highly potent and orally active EZH2 inhibitor with IC50 of 4 nM against mutant EZH2 A677G; significantly reduces cellular H3K27me3 levels in a dose-dependent with IC50 of 8 nM in Pfeffier cell line, IC50 of 55 nM against WSU-DLCL2.
EBI-2511 dose-dependently inhibits tumor growth at 10-100 mg/kg, po.
EBI-2511 shows a superior anti-tumor efficacy to EPZ-6438 in Pfeiffer Xenograft mouse model.
| M.Wt | 576.782 | |
| Formula | C34H48N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-ethyl-6-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-(1-isopropylpiperidin-4-yl)benzofuran-4-carboxamide |
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1. Lu B, et al. ACS Med Chem Lett. 2018 Jan 29;9(2):98-102.
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