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You are here:Home-Chemical Inhibitors & Agonists-Epigenetics-Histone Methyltransferase (HMTase)-CN-SAH
CN-SAH

Chemical Structure : CN-SAH

CAS No.: 1985669-27-9

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CN-SAH (SS148, SS 148, DOT1L inhibitor CN-SAH)

Catalog No.: PC-62736Not For Human Use, Lab Use Only.

CN-SAH is a potent and selective inhibitor of histone methyl transferase DOT1L with IC50 of 26 nM, displays >10-fold selectivity over DNMT1, PRMT3, PRMT5, and G9α..

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CN-SAH (SS148) is a potent and selective inhibitor of histone methyl transferase DOT1L with IC50 of 26 nM, displays >10-fold selectivity over DNMT1, PRMT3, PRMT5, and G9α.
    CN-SAH (SS148) is a potent, selective, SAM competitive inhibitor of SARS-CoV-2 nonstructural protein 14 (nsp14) with IC50/Kd of 70/50 nM, selective against 20 human protein lysine MTases.

    Physicochemical Properties

    M.Wt 408.433
    Formula C16H20N6O5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    S-(((2S,3R,4S,5R)-5-(4-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)-L-homocysteine

    References

    1. Spurr SS, et al. Bioorg Med Chem Lett. 2016 Sep 15;26(18):4518-22.

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