| Cat. No. |
Product Name |
Information |
| PC-49814 |
SMYD3 inhibitor 49
SMYD3 inhibitor
|
SMYD3 inhibitor 49 is a potent and selective SMYD3 inhibitor with IC50 of 6.3 and 44 nM in biochemical and cellular MEKK2me assays, respectively. |
| PC-49699 |
SKLB-03220
EZH2 inhibitor
|
SKLB-03220 (SKLB03220) is a potent, selective EZH2 covalent inhibitor with IC50 of 1.72 nM (EZH2 WT). |
| PC-49683 |
CDIBA
METTL3-14 inhibitor
|
CDIBA is an allosteric inhibitors of m6A-RNA methyltransferase, METTL3 -14 complex with IC50 of 17.3 uM, also reported as a cytosolic phospholipase A2 (cPLA2) inhibitor. |
| PC-49598 |
WDR5 inhibitor 10
WDR5 inhibitor
|
WDR5 inhibitor 10 is a highly potent, selective and orally active inhibitor of WD repeat domain 5 (WDR5) with TR-FRET Ki value of <0.02 nM, shows potent antiproliferative activity with GI50 of 9.7 nM in MV4:11 cells. |
| PC-49506 |
WDR5 WIN site inhibitor 16
WDR5 inhibitor
|
WDR5 WIN site inhibitor 16 is a potent, selective inhibitor of WD repeat domain 5 (WDR5) WIN site with TR-FRET Kd of <0.02 nM, exhibits histone methyltransferase inhibition with IC50 of 2.2 nM. |
| PC-38602 |
MI-3
menin-MLL inhibitor
|
MI-3 is a potent inhibitor of the interaction between menin-MLL with IC50 of 648 nM, binds to menin (Kd = 201 nM) and inhibits the menin-MLL-AF9 interaction in HEK293 cells without affecting protein levels of menin or MLL-AF9. |
| PC-38521 |
WDR5 inhibitor 41
WDR5 inhibitor
|
WDR5 inhibitor 41 is a potent, selective and orally bioavailable WDR5 WIN-site inhibitor with TR-FRET Ki value of <0.02 nM, inhibits cell proliferation of MV4:11 and MOLM-13 with IC50 of 13 and 27 nM, respectively. |
| PC-73099 |
SKI-73
CARM1 inhibitor
|
SKI-73 is a CARM1 chemical probe with pro-drug properties, can readily penetrate cell membranes and then be processed into two active CARM1 inhibitors. |
| PC-72716 |
Compound II757
pan-PRMT inhibitor
|
Compound II757 (II757) is a potent, cell-active pan-PRMT inhibitor with IC50 of 5-555 nM for eight PRMTs, with the highest inhibition for PRMT4 (IC50=5 nM). |
| PC-72468 |
AH237
PRMT4/5 inhibitor
|
AH237 (AH-237) is a potent and selective inhibitor for PRMT4 and PRMT5 with IC50 of 2.8 and 0.42 nM, respectively. |
| PC-72396 |
SGC3027N
PRMT7 inhibitor
|
SGC3027N (SGC-3027N) is a negative control compound for SGC3027, shows markedly less potent (14 uM) against PRMT7 and other protein methyltransferases. |
| PC-72291 |
PRC2 EED-IN-1
PRC2 EED inhibitor
|
PRC2 EED-IN-1 is a potent, selective, allosteric, orally bioavailable inhibitor of the EED subunit of histone methyltransferase PRC2 with IC50 of 44 nM (H3K27me3 inhibition). |
