| Cat. No. |
Product Name |
Information |
| PC-22808 |
AZ-PRMT5i-1
PRMT5 inhibitor
|
AZ-PRMT5i-1 is a potent, selective and MTA-cooperative PRMT5 inhibitor with IC50 of 5.5 nM in symmetrical dimethyl arginine methylation (SDMA) cellular imaging assay. |
| PC-22768 |
DSP-5336
menin-MLL inhibitor
|
DSP-5336 is a potent, and orally bioavailable menin-MLL interaction inhibitor with IC50 of 1.4 nM, directly binds to the menin protein with Kd of 6 nM. |
| PC-22701 |
G9a/NSD2 dual inhibitor 16
G9a/NSD2 inhibitor
|
G9a/NSD2 dual inhibitor 16 (W4032) is a highly potent G9a/NSD2 dual inhibitor with IC50 of 241/17 nM respectively, shows potent cell growth inhibition against PANC-1 and MDA-MB-231 with IC50 values of 0.44 and 0.72 μM, respectively. |
| PC-22471 |
DC-Y13-27
YTHDF2 inhibitor
|
DC-Y13-27 is a specific inhibitor of N6-methyladenosine (m6A) reader YTHDF2, inhibits YTHDF2 binding to m6A-containing RNA with IC50 of 21.8 uM, directly binds to YTHDF2 with a binding constant (KD) of 37.9 uM in MST assay. |
| PC-22428 |
YTHDC1 inhibitor 40
YTHDC1 inhibitor
|
YTHDC1 inhibitor 40 is a potent, selective m6A reader YTHDC1 inhibitor with ITC Kd of 49 nM, HTRF IC50 of 0.35 uM. |
| PC-22354 |
PRMT9 inhibitor LD2
PRMT9 inhibitor
|
PRMT9 inhibitor LD2 is a specific small molecule PRMT9 inhibitor, inhibits PABPC1 R493 methylation level with IC50 of 0.9 uM in in Molm13s, sparing other PRMTs. |
| PC-22335 |
iCARM1
CARM1 inhibitor
|
iCARM1 (ZINC65534584) is a potent, selective inhibitor of protein arginine methyltransferase CARM1 (PRMT4) with IC50 of 12.3 uM, Biacore Kd of 0.67 uM. |
| PC-22311 |
WDR5 WIN site inhibitor C6 TFA
WDR5 inhibitor
|
WDR5 inhibitor C6 TFA is a highly potent WDR5 WIN site inhibitor with Kd of 0.1 nM.
|
| PC-22295 |
NSD2-PWWP1 inhibitor 34
NSD2-PWWP1 inhibitor
|
NSD2-PWWP1 inhibitor 34 is a potent, selective NSD2-PWWP1 binder / inhibitor with pIC50 of 8.2, pKd of 8.6. |
| PC-22291 |
AZ39
SMYD2 inhibitor
|
AZ39 is a potent, selective inhibitor of protein lysine methyltransferase SMYD2 with IC50 of 28 nM, inhibits SMYD2 mediated methylation of monomethyl p53 peptide in U2OS cells with IC50 of 280 nM. |
| PC-22290 |
AZ506
SMYD2 inhibitor
|
AZ506 is a potent, selective inhibitor of protein lysine methyltransferase SMYD2 with IC50 of 17 nM, inhibits SMYD2 mediated methylation of monomethyl p53 peptide in U2OS cells with IC50 of 1.02 uM. |
| PC-22134 |
TNG462
PRMT5 inhibitor
|
TNG462 (TNG-462) is a potent, selective, MTA-cooperative PRMT5 inhibitor, selective inhibits MTAP-deleted cancer cell lines. |
