| Cat. No. |
Product Name |
Information |
| PC-42923 |
MM-102 trifluoroacetate
MLL1/WDR5 inhibitor
|
MM-102 trifluoroacetate is a high-affinity, small-molecule peptidomimetic inhibitor of MLL1/WDR5 protein-protein interaction with Ki of 2.4 nM. |
| PC-42922 |
MM-102
MLL1/WDR5 inhibitor
|
MM-102 is a high-affinity, small-molecule peptidomimetic inhibitor of MLL1/WDR5 protein-protein interaction with Ki of 2.4 nM. |
| PC-45489 |
PFI-2 hydrochloride
SETD7 inhibitor
|
PFI-2 ((R)-PFI-2) hydrochloride is a first-in-class, potent and selective inhibitor of SETD7 methyltransferase with Ki app/IC50 of 0.33/2 nM, respectively. |
| PC-45488 |
PFI-2
SETD7 inhibitor
|
PFI-2 ((R)-PFI-2) is a first-in-class, potent and selective inhibitor of SETD7 methyltransferase with Ki app/IC50 of 0.33/2 nM, respectively. |
| PC-25447 |
DNMT2 inhibitor 16
DNMT2 inhibitor
|
DNMT2 inhibitor 16 is a potent, selective DNMT2 (TRDMT1) inhibitor with ITC KD of 3.04 uM, reduces m5C levels in MOLM-13 tRNA and synergizes with doxorubicin to impair cell viability, targeting a cryptic allosteric binding site. |
| PC-25345 |
SKLB-Y13
YTHDF1 inhibitor
|
SKLB-Y13 is the first, selective small-molecule inhibitor targeting of the YTHDF1 m6A-binding pocket with IC50 of 0.76 uM, has selectivity for YTHDF1 over YTH family proteins. |
| PC-25322 |
IACS-17817
NSD2 inhibitor
|
IACS-17817 is a highly potent, selective and SAM-competitive inhibitor of NSD2 (MMSET, WHSC1) with IC50 of 19.0 nM, >50-fold selective over a KMT panel including NSD1, NSD3 and SETD2.
IACS-17817 inhibits NSD2 methylation of nucleosome substrates in vitro with IC50 of 19.0 nM. |
| PC-25273 |
UNC0646
G9a inhibitor
|
UNC0646 (UNC 0646) is a potent, selective and cell-active inhibitor of G9a methyltransferase with IC50 of 6 nM in SAHH-coupled assays, reduces H3K9me2 levels in MDA-MB-231 cells with IC50 of 26 nM. |
| PC-25272 |
UNC0631
G9a inhibitor
|
UNC0631 (UNC 0631) is a potent, selective and cell-active inhibitor of G9a methyltransferase with IC50 of 4 nM in SAHH-coupled assays, reduces H3K9me2 levels in MDA-MB-231 cells with IC50 of 25 nM. |
| PC-25006 |
SHR2554
EZH2 inhibitor
|
Zeprumetostat (SHR2554) is a potent, highly selective EZH2 inhibitor, specifically inhibits both wild-type (IC50=0.87 nM) and mutant (EZH2(Y641F), IC50=2.68 nM) EZH2 methyltransferase activity with similar potencies. |
| PC-24896 |
KMT9 inhibitor 7b
KMT9 inhibitor
|
KMT9 inhibitor 7b is a potent and selective lysine methyltransferase 9 (KMT9) inhibitor with Kd of 10 nM. |
| PC-24895 |
KMT9 inhibitor 8
KMT9 inhibitor
|
KMT9 inhibitor 8 is the ethyl ester prodrug of KMT9 inhibitor 7b, a potent and selective lysine methyltransferase 9 (KMT9) inhibitor with Kd of 10 nM. |
