| Cat. No. |
Product Name |
Information |
| PC-22335 |
iCARM1
CARM1 inhibitor
|
iCARM1 (ZINC65534584) is a potent, selective inhibitor of protein arginine methyltransferase CARM1 (PRMT4) with IC50 of 12.3 uM, Biacore Kd of 0.67 uM. |
| PC-22311 |
WDR5 WIN site inhibitor C6 TFA
WDR5 inhibitor
|
WDR5 inhibitor C6 TFA is a highly potent WDR5 WIN site inhibitor with Kd of 0.1 nM.
|
| PC-22295 |
NSD2-PWWP1 inhibitor 34
NSD2-PWWP1 inhibitor
|
NSD2-PWWP1 inhibitor 34 is a potent, selective NSD2-PWWP1 binder / inhibitor with pIC50 of 8.2, pKd of 8.6. |
| PC-22291 |
AZ39
SMYD2 inhibitor
|
AZ39 is a potent, selective inhibitor of protein lysine methyltransferase SMYD2 with IC50 of 28 nM, inhibits SMYD2 mediated methylation of monomethyl p53 peptide in U2OS cells with IC50 of 280 nM. |
| PC-22290 |
AZ506
SMYD2 inhibitor
|
AZ506 is a potent, selective inhibitor of protein lysine methyltransferase SMYD2 with IC50 of 17 nM, inhibits SMYD2 mediated methylation of monomethyl p53 peptide in U2OS cells with IC50 of 1.02 uM. |
| PC-22134 |
TNG462
PRMT5 inhibitor
|
TNG462 (TNG-462) is a potent, selective, MTA-cooperative PRMT5 inhibitor, selective inhibits MTAP-deleted cancer cell lines. |
| PC-22132 |
TNG908
PRMT5 inhibitor
|
TNG908 (TNG-908) is a potent, selective, brain penetrant, MTA-cooperative PRMT5 inhibitor with IC50 of 9 nM in SDMA in-cell western assay, binds the PRMT5·MTA complex, selectively kills MTAP-deleted (MTAP-null) cells. |
| PC-22119 |
ORIC-944
PRC2 inhibitor
|
ORIC-944 (ORIC944) is a potent, selective, allosteric and orally bioavailable PRC2 inhibitor with EED binding EC50 of 106 pM and biochemical PRC2 EC50 of 16.7 nM. |
| PC-22053 |
MS8535
SPIN1 inhibitor
|
MS8535 is a potent, selective and cell-active inhibitor of methyl-lysine reader protein SPIN1 with biochemical IC50 of 202 nM and ITC binding Kd of 30 nM. |
| PC-21951 |
EPZ005687
EZH2 inhibitor
|
EPZ005687 is a potent, selective and SAM-competitive inhibitor of EZH2 with Ki of 24 nM, 50-fold selectivity over EZH1 and 500-fold selectivity against 15 other protein methyltransferases. |
| PC-21940 |
UNC1999
EZH2 inhibitor
|
UNC1999 is a potent, selectice SAM-competitive and orally bioavailable inhibitor of EZH2/EZH1 with IC50 of <10 nM/45 nM, respectively. |
| PC-21939 |
GSK126
EZH2 inhibitor
|
GSK126 (GSK2816126A) is a potent, highly selective, and SAM-competitive inhibitor of EZH2 methyltransferase with IC50 of 9.9 nM. |
