Chemical Structure : KMT9 inhibitor 8
CAS No.:
2625406-61-1
KMT9 inhibitor 8
Catalog No.: PC-24895Not For Human Use, Lab Use Only.
KMT9 inhibitor 8 is the ethyl ester prodrug of KMT9 inhibitor 7b, a potent and selective lysine methyltransferase 9 (KMT9) inhibitor with Kd of 10 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
KMT9 inhibitor 8 is the ethyl ester prodrug of KMT9 inhibitor 7b, a potent and selective lysine methyltransferase 9 (KMT9) inhibitor with Kd of 10 nM.
KMT9 inhibitor 8 exhibits cellular target engagement and reduces cellular levels of histone H4K12 monomethylation.
KMT9 inhibitor 8 specifically blocks proliferation of colon cancer cells.
KMT9 inhibitor 8 is a tool compound to investigate the function of KMT9 in cells.
Physicochemical Properties
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M.Wt
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712.26
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Formula
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C36H47ClFN7O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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Ethyl (S)-2-amino-4-((3-((4-(4-chlorophenoxy)-3-fluorophenethyl)amino)propyl) (((1R,2R,3S,4R)-2,3-dihydroxy-4-(4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl) cyclopentyl)methyl)amino)butanoate
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References
1. Wang S, et al. J Med Chem. 2025 Jun 17. doi: 10.1021/acs.jmedchem.4c02953.
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