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You are here:Home-Chemical Inhibitors & Agonists-Epigenetics-Histone Methyltransferase (HMTase)-UNC0631
UNC0631

Chemical Structure : UNC0631

CAS No.: 1320288-19-4

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UNC0631 (UNC-0631, UNC 0631)

Catalog No.: PC-25272Not For Human Use, Lab Use Only.

UNC0631 (UNC 0631) is a potent, selective and cell-active inhibitor of G9a methyltransferase with IC50 of 4 nM in SAHH-coupled assays, reduces H3K9me2 levels in MDA-MB-231 cells with IC50 of 25 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

UNC0631 (UNC 0631) is a potent, selective and cell-active inhibitor of G9a methyltransferase with IC50 of 4 nM in SAHH-coupled assays, reduces H3K9me2 levels in MDA-MB-231 cells with IC50 of 25 nM.

Physicochemical Properties

M.Wt 635.94
Formula C37H61N7O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(1-(Cyclohexylmethyl)piperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine

References

1. Liu F, et al. J Med Chem. 2011 Sep 8;54(17):6139-50.

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