| Cat. No. |
Product Name |
Information |
| PC-72365 |
TDI-6118
EZH2 inhibitor
|
TDI-6118 is a potent, selective brain-penetrant EZH2 inhibitor with IC50 of 14 nM, inhibits cellular H3K27me with IC50 of 580 nM. |
| PC-72317 |
EPZ-719
SETD2 inhibitor
|
EPZ-719 (EPZ 719) is a potent, selective SETD2 histone methyltransferase inhibitor with IC50 of 8 nM. |
| PC-72299 |
NSD1 inhibitor BT5
NSD1 inhibitor
|
NSD1 inhibitor BT5 is a covalent, small molecule inhibitor of NSD1 histone methyltransferase with IC50 of 1.4 uM, shows no covalent binding to NSD2. |
| PC-72295 |
SW2_152F
CBX2 inhibitor
|
SW2_152F (SW2 152F, SW2-152F) is a potent, selective, cell permeable CBX2 chromodomain probe, binds to the N-terminal chromodomain (ChD) with Kd of 80 nM. |
| PC-72294 |
BI-9321 trihydrochloride
NSD3-PWWP1 inhibitor
|
BI-9321 trihydrochloride (BI 9321) is a potent, selective and cellular active inhibitor of the NSD3-PWWP1 domain with SPR Kd of 166 nM. |
| PC-72293 |
BI-9321
NSD3-PWWP1 inhibitor
|
BI-9321 (BI 9321) is a potent, selective and cellular active inhibitor of the NSD3-PWWP1 domain with SPR Kd of 166 nM. |
| PC-72292 |
MR837
NSD2-PWWP1 inhibitor
|
MR837 (NSD2-PWWP1 inhibitor 3f) is a small-molecule antagonist (inhibitor) that binds to the NSD2-PWWP1 domain (SPR Kd=3.4 uM, NSD2 IC50=17.3 uM), abrogates histone H3K36me2 binding to the PWWP1 domain in cells. |
| PC-72291 |
PRC2 EED-IN-1
PRC2 EED inhibitor
|
PRC2 EED-IN-1 is a potent, selective, allosteric, orally bioavailable inhibitor of the EED subunit of histone methyltransferase PRC2 with IC50 of 44 nM (H3K27me3 inhibition). |
| PC-72290 |
OR-S0
EZH2 inhibitor
|
OR-S0 is a potent, selective EZH2 inhibitor with IC50 of 11 nM, weakly inhibitor EZH1 (IC50=91 nM). |
| PC-72288 |
ZLD1039
EZH2 inhibitor
|
ZLD1039 (ZLD 1039) is a potent, highly selective, and orally bioavailable small molecule inhibitor of EZH2 with IC50 of 5.6, 15, 4.0 nM against EZH2 WT, Y641F, and A677G mutations respectively. |
| PC-72287 |
SKLB-03176
EZH2 inhibitor
|
SKLB-03176 (SKLB03176) is a potent, selective, covalent EZH2 inhibitor with IC50 of 47 nM, covalently binds to the SAM pocket of EZH2. |
| PC-72046 |
MI-3454
menin-MLL1 inhibitor
|
MI-3454 (MI 3454) is a highly potent, orally bioavailable inhibitor of the menin-MLL1 interaction with IC50 of 0.51 nM, 60-fold improvement over MI-503. |
