| Cat. No. |
Product Name |
Information |
| PC-72396 |
SGC3027N
PRMT7 inhibitor
|
SGC3027N (SGC-3027N) is a negative control compound for SGC3027, shows markedly less potent (14 uM) against PRMT7 and other protein methyltransferases. |
| PC-72395 |
SGC8158
PRMT7 inhibitor
|
SGC8158 (SGC-8158) is a potent, selective, and SAM-competitive inhibitor of PRMT7 with IC50 of <2.5 nM, the active component of it's cell permeable prodrug SGC3027. |
| PC-72394 |
SGC3027
PRMT7 inhibitor
|
SGC3027 (SGC-3027) is the cell permeable prodrug of SGC8158, a potent, selective, and SAM-competitive inhibitor of PRMT7 with IC50 of <2.5 nM. |
| PC-72393 |
MRTX1719
PRMT5 inhibitor
|
MRTX1719 (MRTX-1719) is a potent, selective binder to the PRMT5-MTA complex, selectively inhibits PRMT5 activity in MTAP-deleted cells (HCT116 MTAP-deleted IC50=12 nM) compared to MTAP-wild-type cells. |
| PC-72366 |
TDI-11904
EZH2 inhibitor
|
TDI-11904 is a highly potent, and peripherally active EZH2 inhibitor with IC50 of 0.9 nM, inhibits H3K27me3 with IC50 of 6.0 nM in cellular EZH2 inhibition assay. |
| PC-72365 |
TDI-6118
EZH2 inhibitor
|
TDI-6118 is a potent, selective brain-penetrant EZH2 inhibitor with IC50 of 14 nM, inhibits cellular H3K27me with IC50 of 580 nM. |
| PC-72317 |
EPZ-719
SETD2 inhibitor
|
EPZ-719 (EPZ 719) is a potent, selective SETD2 histone methyltransferase inhibitor with IC50 of 8 nM. |
| PC-72299 |
NSD1 inhibitor BT5
NSD1 inhibitor
|
NSD1 inhibitor BT5 is a covalent, small molecule inhibitor of NSD1 histone methyltransferase with IC50 of 1.4 uM, shows no covalent binding to NSD2. |
| PC-72295 |
SW2_152F
CBX2 inhibitor
|
SW2_152F (SW2 152F, SW2-152F) is a potent, selective, cell permeable CBX2 chromodomain probe, binds to the N-terminal chromodomain (ChD) with Kd of 80 nM. |
| PC-72294 |
BI-9321 trihydrochloride
NSD3-PWWP1 inhibitor
|
BI-9321 trihydrochloride (BI 9321) is a potent, selective and cellular active inhibitor of the NSD3-PWWP1 domain with SPR Kd of 166 nM. |
| PC-72293 |
BI-9321
NSD3-PWWP1 inhibitor
|
BI-9321 (BI 9321) is a potent, selective and cellular active inhibitor of the NSD3-PWWP1 domain with SPR Kd of 166 nM. |
| PC-72292 |
MR837
NSD2-PWWP1 inhibitor
|
MR837 (NSD2-PWWP1 inhibitor 3f) is a small-molecule antagonist (inhibitor) that binds to the NSD2-PWWP1 domain (SPR Kd=3.4 uM, NSD2 IC50=17.3 uM), abrogates histone H3K36me2 binding to the PWWP1 domain in cells. |
