| Cat. No. |
Product Name |
Information |
| PC-72471 |
MS4322
PRMT5 degrader
|
MS4322 (MS-4322) is a potent, highly selective PRMT5 degrader (PROTAC) by linking the PRMT5 inhibitor EPZ015666 to a von Hippel-Lindau (VHL) E3 ligase ligand, with PRMT5 protein DC50 of 1.1 uM in MCF-7 cells. |
| PC-72468 |
AH237
PRMT4/5 inhibitor
|
AH237 (AH-237) is a potent and selective inhibitor for PRMT4 and PRMT5 with IC50 of 2.8 and 0.42 nM, respectively. |
| PC-72444 |
JNJ-64619178
PRMT5 inhibitor
|
JNJ-64619178 (Onametostat, JNJ 64619178) is a selective, and potent PRMT5 inhibitor with Kiapp of 0.77 nM, inhibits the PRMT5/MEP50 complex impairing cancer cell proliferation. |
| PC-72438 |
KO-539
menin-MLL inhibitor
|
KO-539 (Ziftomenib, KO 539) is a potent and selective menin-MLL inhibitor under clinical investigation for treatment of acute myeloid leukemia (AML). |
| PC-72396 |
SGC3027N
PRMT7 inhibitor
|
SGC3027N (SGC-3027N) is a negative control compound for SGC3027, shows markedly less potent (14 uM) against PRMT7 and other protein methyltransferases. |
| PC-72395 |
SGC8158
PRMT7 inhibitor
|
SGC8158 (SGC-8158) is a potent, selective, and SAM-competitive inhibitor of PRMT7 with IC50 of <2.5 nM, the active component of it's cell permeable prodrug SGC3027. |
| PC-72394 |
SGC3027
PRMT7 inhibitor
|
SGC3027 (SGC-3027) is the cell permeable prodrug of SGC8158, a potent, selective, and SAM-competitive inhibitor of PRMT7 with IC50 of <2.5 nM. |
| PC-72393 |
MRTX1719
PRMT5 inhibitor
|
Navlimetostat (MRTX1719, MRTX-1719) is a potent, selective binder to the PRMT5-MTA complex, selectively inhibits PRMT5 activity in MTAP-deleted cells (HCT116 MTAP-deleted IC50=12 nM) compared to MTAP-wild-type cells. |
| PC-72366 |
TDI-11904
EZH2 inhibitor
|
TDI-11904 is a highly potent, and peripherally active EZH2 inhibitor with IC50 of 0.9 nM, inhibits H3K27me3 with IC50 of 6.0 nM in cellular EZH2 inhibition assay. |
| PC-72365 |
TDI-6118
EZH2 inhibitor
|
TDI-6118 is a potent, selective brain-penetrant EZH2 inhibitor with IC50 of 14 nM, inhibits cellular H3K27me with IC50 of 580 nM. |
| PC-72317 |
EPZ-719
SETD2 inhibitor
|
EPZ-719 (EPZ 719) is a potent, selective SETD2 histone methyltransferase inhibitor with IC50 of 8 nM. |
| PC-72299 |
NSD1 inhibitor BT5
NSD1 inhibitor
|
NSD1 inhibitor BT5 is a covalent, small molecule inhibitor of NSD1 histone methyltransferase with IC50 of 1.4 uM, shows no covalent binding to NSD2. |
