You are here:Home-Chemical Inhibitors & Agonists-Epigenetics-Histone Methyltransferase (HMTase)

Request The Product List ofHistone Methyltransferase (HMTase) Histone Methyltransferase (HMTase)

Cat. No. Product Name Information
PC-63135

MS0124

G9a-like protein inhibitor

MS-0124 is a potent and selective inhibitor of G9a-like Protein (GLP) lysine methyltransferase with IC50 of 13 nM, shows >30-fold selectivity for GLP over G9a and other methyltransferases..
PC-62981

CMP-5

PRMT5 inhibitor

CMP-5 (PRMT5-IN-5)is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival, without effect on normal B cells.
PC-62758

Chaetocin

SU(VAR)3-9 HMTase inhibitor

Chaetocin is a potent, specific, SAM-competitive inhibitor of histone H3K9 methyltransferase (HMT) SU(VAR)3-9 with IC50 of 0.6 uM, no actiivty against H4 Lys20-specific HMT PRSET7 and SET7/9.
PC-62736

CN-SAH

DOT1L inhibitor

CN-SAH is a potent and selective inhibitor of histone methyl transferase DOT1L with IC50 of 26 nM, displays >10-fold selectivity over DNMT1, PRMT3, PRMT5, and G9α..
PC-62527

PF-06726304

EZH2 inhibitor

PF-06726304 is a novel potent enhancer of zeste homolog 2 (EZH2) inhibitor with IC50 of <5 nM, Ki of 0.7/3.0 nM (Wt/Y641N).
PC-62526

EBI-2511

EZH2 inhibitor

EBI-2511 is a highly potent and orally active EZH2 inhibitor with IC50 of 4 nM against mutant EZH2 A677G.
PC-62486

M-525

Menin-MLL inhibitor

M-525 is a first-in-class, highly potent, irreversible small-molecule inhibitor of the menin-MLL interaction with binding IC50 of 3.3 nM in FP assays.
PC-62485

MI-2-2

Menin-MLL inhibitor

MI-2-2 is a potent inhibitor of the menin-MLL interaction that binds to menin with low nanomolar affinity (Kd=22 nM).
PC-62409

MMSET-IN-1

NSD2 inhibitor

MMSET-IN-1 (NSD2 inhibitor 1) is a potent, selective epigenetic oncogene MMSET (aka NSD2 or WHSC1) inhibitor with Ki/IC50 of 1.6/3.3 uM.
PC-62385

UNC-2170 maleate

53BP1 inhibitor

UNC-2170 maleate is a small molecule ligand for the methyl-lysine binding protein 53BP1 (p53-binding protein 1) with Kd of 22 uM against the 53BP1 tandem tudor domain.
PC-62384

UNC-2170

53BP1 inhibitor

UNC-2170 is a small molecule ligand for the methyl-lysine binding protein 53BP1 (p53-binding protein 1) with Kd of 22 uM against the 53BP1 tandem tudor domain.
PC-62309

A-395

EED inhibitor

A-395 (A395) is a potent, selective, and cellularly active PRC2 subunit EED inhibitor with Kd of 1.5 nM.

Request The Product List

* Indicates a Required FieldYour information is safe with us.

  • *Product List:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Country:
  • Additional Information:

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com