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Chemical Structure : SGC6870
Catalog No.: PC-72639Not For Human Use, Lab Use Only.
SGC6870 (SGC-6870 (R-isomer)) is a potent, selective, cell-active PRMT6 inhibitor with IC50 of 77 nM.
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SGC6870 (SGC-6870 (R-isomer)) is a potent, selective, cell-active PRMT6 inhibitor with IC50 of 77 nM.
SGC6870 displays outstanding selectivity for PRMT6 over a broad panel of other methyltransferases and nonepigenetic targets.
SGC6870 binds to a unique, induced allosteric pocket of PRMT6.
SGC6870 engages PRMT6 and potently inhibits its methyltransferase activity in cells.
SGC6870 is a well-characterized PRMT6 chemical probe and a valuable tool for further investigating PRMT6 functions in health and disease.
| M.Wt | 469.397 | |
| Formula | C23H21BrN2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yudao Shen, et al. J Med Chem. 2021 Apr 8;64(7):3697-3706.
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