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SGC6870

Chemical Structure : SGC6870

CAS No.: 2561471-27-8

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SGC6870 (SGC-6870 (R-isomer))

Catalog No.: PC-72639Not For Human Use, Lab Use Only.

SGC6870 (SGC-6870 (R-isomer)) is a potent, selective, cell-active PRMT6 inhibitor with IC50 of 77 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SGC6870 (SGC-6870 (R-isomer)) is a potent, selective, cell-active PRMT6 inhibitor with IC50 of 77 nM.
    SGC6870 displays outstanding selectivity for PRMT6 over a broad panel of other methyltransferases and nonepigenetic targets.
    SGC6870 binds to a unique, induced allosteric pocket of PRMT6.
    SGC6870 engages PRMT6 and potently inhibits its methyltransferase activity in cells.
    SGC6870 is a well-characterized PRMT6 chemical probe and a valuable tool for further investigating PRMT6 functions in health and disease.

    Physicochemical Properties

    M.Wt 469.397
    Formula C23H21BrN2O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-4-(5-Bromothiophene-2-carbonyl)-5-(3,5-dimethylphenyl)-7-methyl-1,3,4,5-tetrahydro-2H-benzo[e][1,4]diazepin-2-one

    References

    1. Yudao Shen, et al. J Med Chem. 2021 Apr 8;64(7):3697-3706.

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