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Chemical Structure : VTP50469
CAS No.: 2169916-18-9
Catalog No.: PC-72792Not For Human Use, Lab Use Only.
VTP50469 (VTP 50469) is potent, selective, orally active inhibitor of Menin-MLL interaction with Ki of 104 pM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $328 | In stock | |
| 50 mg | $788 | In stock | |
| 100 mg | $1280 | In stock | |
| 1 g | Get quote |
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VTP50469 (VTP 50469, SNDX-50469) is potent, selective, orally active inhibitor of Menin-MLL interaction with Ki of 104 pM.
VTP50469 treatment led to a profound reduction in cell proliferation in a concentration-dependent manner in MLL-r cell lines carrying but not in those with WT MLL (HL-60, REH, K562, murine MOZ-TIF2).
VTP50469 treatment rapidly suppresses MLL-fusion target gene expression, induces global changes in Menin and selective changes in MLL chromatin occupancy.
VTP50469 treatment can eradicate disease in PDX models of MLL-r acute leukemia.
| M.Wt | 630.3364 | |
| Formula | C32H47FN6O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-Fluoro-N,N-diisopropyl-2-((4-(7-(((1r,4r)-4-(methylsulfonamido)cyclohexyl)methyl)-2,7-diazaspiro[3.5]nonan-2-yl)pyrimidin-5-yl)oxy)benzamide |
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1. Krivtsov AV, et al. Cancer Cell. 2019 Dec 9;36(6):660-673.e11.
2. Heikamp EB, et al. Blood. 2021 Sep 28:blood.2021012806.
3. Warren Fiskus, et al. Blood Cancer J. 2022 Jan 11;12(1):5.
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