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Chemical Structure : SPIN1 inhibitor MS31
CAS No.: 2366264-12-0
Catalog No.: PC-73027Not For Human Use, Lab Use Only.
SPIN1 inhibitor MS31 (MS31) is a potent, selective, and cell-active inhibitor of methyllysine reader protein SPIN1 (spindlin 1) with IC50 of 77 nM.
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SPIN1 inhibitor MS31 (MS31) is a potent, selective, and cell-active inhibitor of methyllysine reader protein SPIN1 (spindlin 1) with IC50 of 77 nM.
MS31 potently inhibited binding of trimethyllysine-containing peptides to SPIN1.
MS31 displayed high binding affinity, was highly selective for SPIN1 over other epigenetic readers and writers (G9a/GLP, inactive).
MS31 directly engaged SPIN1 in cells, and was not toxic to nontumorigenic cells.
MS31 selectively binds tudor domain II of SPIN1 (KD=91 nM).
| M.Wt | 341.455 | |
| Formula | C20H27N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(5-(3-(isoindolin-2-yl)propoxy)-4-methoxy-1,3-phenylene)dimethanamine |
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1. Xiong Y, et al. J Med Chem. 2019 Oct 24;62(20):8996-9007
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