Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : SPIN1 inhibitor MS31
CAS No.: 2366264-12-0
Catalog No.: PC-73027Not For Human Use, Lab Use Only.
SPIN1 inhibitor MS31 (MS31) is a potent, selective, and cell-active inhibitor of methyllysine reader protein SPIN1 (spindlin 1) with IC50 of 77 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $388 | In stock | |
| 10 mg | $588 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
SPIN1 inhibitor MS31 (MS31) is a potent, selective, and cell-active inhibitor of methyllysine reader protein SPIN1 (spindlin 1) with IC50 of 77 nM.
MS31 potently inhibited binding of trimethyllysine-containing peptides to SPIN1.
MS31 displayed high binding affinity, was highly selective for SPIN1 over other epigenetic readers and writers (G9a/GLP, inactive).
MS31 directly engaged SPIN1 in cells, and was not toxic to nontumorigenic cells.
MS31 selectively binds tudor domain II of SPIN1 (KD=91 nM).
| M.Wt | 341.455 | |
| Formula | C20H27N3O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(5-(3-(isoindolin-2-yl)propoxy)-4-methoxy-1,3-phenylene)dimethanamine |
|
1. Xiong Y, et al. J Med Chem. 2019 Oct 24;62(20):8996-9007
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
