| Cat. No. |
Product Name |
Information |
| PC-22295 |
NSD2-PWWP1 inhibitor 34
NSD2-PWWP1 inhibitor
|
NSD2-PWWP1 inhibitor 34 is a potent, selective NSD2-PWWP1 binder / inhibitor with pIC50 of 8.2, pKd of 8.6. |
| PC-22291 |
AZ39
SMYD2 inhibitor
|
AZ39 is a potent, selective inhibitor of protein lysine methyltransferase SMYD2 with IC50 of 28 nM, inhibits SMYD2 mediated methylation of monomethyl p53 peptide in U2OS cells with IC50 of 280 nM. |
| PC-22290 |
AZ506
SMYD2 inhibitor
|
AZ506 is a potent, selective inhibitor of protein lysine methyltransferase SMYD2 with IC50 of 17 nM, inhibits SMYD2 mediated methylation of monomethyl p53 peptide in U2OS cells with IC50 of 1.02 uM. |
| PC-22119 |
ORIC-944
PRC2 inhibitor
|
ORIC-944 (ORIC944) is a potent, selective, allosteric and orally bioavailable PRC2 inhibitor with EED binding EC50 of 106 pM and biochemical PRC2 EC50 of 16.7 nM. |
| PC-21951 |
EPZ005687
EZH2 inhibitor
|
EPZ005687 is a potent, selective and SAM-competitive inhibitor of EZH2 with Ki of 24 nM, 50-fold selectivity over EZH1 and 500-fold selectivity against 15 other protein methyltransferases. |
| PC-21940 |
UNC1999
EZH2 inhibitor
|
UNC1999 is a potent, selectice SAM-competitive and orally bioavailable inhibitor of EZH2/EZH1 with IC50 of <10 nM/45 nM, respectively. |
| PC-21939 |
GSK126
EZH2 inhibitor
|
GSK126 (GSK2816126A) is a potent, highly selective, and SAM-competitive inhibitor of EZH2 methyltransferase with IC50 of 9.9 nM. |
| PC-21930 |
CPI-360
EZH2 inhibitor
|
CPI-360 is a potent, selective EZH2 inhibitor with IC50 of 0.5 and 2.5 nM for wild-type EZH2 and Y641N mutant EZH2, respectively. |
| PC-21832 |
WDR5 WBM site inhibitor 7k
WDR5 WBM site inhibitor
|
WDR5 WBM site inhibitor 7k is a selective small molecule inhibitor of WDR5 WBM binding site with Ki of 107 nM, inhibits lncRNA-WDR5 complex formation. |
| PC-21568 |
BN104
menin-MLL inhibitor
|
BN104 (BNM-1192) is a potent, highly selective small molecule menin-MLL inhibitor, BNM-1192 is very potent against leukemia cell lines with MLL-fusion protein and NPM1 mutant (MV-4-11 (AF4 fusion), IC50=3.5 nM). |
| PC-21490 |
UNC7648
53BP1 inhibitor
|
UNC7648 is a small molecule inhibitor of the methyl-lysine reader p53 binding protein 1 (53BP1) tandem Tudor domain (TTD) with TR-FRET IC50 of 8.6 uM. |
| PC-21489 |
UNC9512
53BP1 inhibitor
|
UNC9512 is a selective methyl-lysine reader p53 binding protein 1 (53BP1) antagonist, binds the 53BP1 tandem Tudor domain (TTD) with TR-FRET IC50 of 0.46 uM, and SPR/ITC Kd vfalues of 0.17/0.41 uM respectively. |
