| Cat. No. |
Product Name |
Information |
| PC-26274 |
SGSS05NS
SETD8 inhibitor
|
SGSS05NS is a potent, selective and covalent inhibitor of protein lysine methyltransferase (PKMT) SETD8 with IC50 of 0.54 uM, covalently modifies SETD8 at Cys311. |
| PC-26273 |
MS4138
SETD8 inhibitor
|
MS4138 is a potent, selective and covalent inhibitor of protein lysine methyltransferase (PKMT) SETD8 with IC50 of 1.4 uM, covalently modifies SETD8 at Cys311. |
| PC-26271 |
MS2928
SETD8 inhibitor
|
MS2928 is a potent and selective SETD8 covalent inhibitor, inhibits SETD8 methyltransferase activity with IC50 of 0.14 uM, covalently modifies SETD8 at Cys311. |
| PC-26182 |
AC1Q3QWB
HOTAIR-EZH2 inhibitor
|
AC1Q3QWB (ACB) is a selective and efficient inhibitor of HOTAIR-EZH2 interaction with IC50 of 42.47 nM, exhibits potent anti-tumor activity in cancer cells expressing high levels of HOTAIR and EZH2. |
| PC-25966 |
SKLB06489
Type I PRMTs inhibitor
|
SKLB06489 is a potent, selective type I PRMTs inhibitor with IC50 of 64.55, 4.21, and 51.27 nM for PRMT1, PRMT6, and PRMT8 respectively. |
| PC-25913 |
DCG066
G9a inhibitor
|
DCG066 is a novel small molecule inhibitors of lysine methyltransferase G9a, inhibits G9a methyltransferase activity with IC50 of 6.5 uM. |
| PC-25711 |
Heterochromatin protein 1 inhibitor (R)-18
HP1 inhibitor
|
Heterochromatin protein 1 inhibitor (R)-18 is a small-molecule inhibitor of heterochromatin protein 1 (HP1), inhibits the HP1/H3K9me3 interaction with IC50 of 18.1 uM. |
| PC-25566 |
BMF-219
Menin inhibitor
|
BMF-219 (Icovamenib) is a potent, selective and covalent irreversible menin inhibitor, inhibits the growth of KRAS-mutated solid tumors with G12C, G12D, and G12V KRAS mutations. |
| PC-25565 |
RK-552
NSD2 inhibitor
|
RK-0080552 (RK-552) is a potent, specific small molecule NSD2 inhibitor with IC50 of 0.11 uM, weakly inhibits G9a (IC50=1.2 uM) and does not inhibit SET7/9. |
| PC-25506 |
LH168
WDR5 inhibitor
|
LH168 is a potent, exquisitely selective WDR5 chemical probe inhibitor with EC50 of 10 nM in cellulo target engagement NanoBRET assays, SPR KD of 1.9 nM. |
| PC-25447 |
DNMT2 inhibitor 16
DNMT2 inhibitor
|
DNMT2 inhibitor 16 is a potent, selective DNMT2 (TRDMT1) inhibitor with ITC KD of 3.04 uM, reduces m5C levels in MOLM-13 tRNA and synergizes with doxorubicin to impair cell viability, targeting a cryptic allosteric binding site. |
| PC-25322 |
IACS-17817
NSD2 inhibitor
|
IACS-17817 is a highly potent, selective and SAM-competitive inhibitor of NSD2 (MMSET, WHSC1) with IC50 of 19.0 nM, >50-fold selective over a KMT panel including NSD1, NSD3 and SETD2.
IACS-17817 inhibits NSD2 methylation of nucleosome substrates in vitro with IC50 of 19.0 nM. |
