Chemical Structure : Igermetostat
CAS No.:
2409538-60-7
Igermetostat
(XNW-5004, XNW5004)
Catalog No.: PC-23098Not For Human Use, Lab Use Only.
Igermetostat (XNW5004) is a potent, selective EZH2 inhibitor which potently inhibits both wild type and mutant EZH2.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Igermetostat (XNW5004) is a potent, selective EZH2 inhibitor which potently inhibits both wild type and mutant EZH2.
XNW5004 significantly suppresses level of H3K27Me3, arrests cell cycle in G1/S phase and promotes apoptosis in tumor.
XNW5004 exhibits strong antitumor activity in EZH2-mutant lymphoma xenograft models, such as Karpas422 (Y641N), Pfeiffer (A677G) and SU-DHL-10 (Y641F).
XNW5004 exhibits dose-dependent efficacy in solid tumor models such as G401 (SMARCB1 deficient) and COV434 (SMARCA2/SMARCA4 deficient) cancer cell lines and xenografts.
Physicochemical Properties
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M.Wt
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550.74
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Formula
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C32H46N4O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-2-methyl-5-[[trans-3-(1-piperidinyl)cyclobutyl]oxy]benzamide
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References
1. Yonghan Hu, et al. Cancer Res (2023) 83 (7_Supplement): 3089.
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