YD1130

Chemical Structure : YD1130

Catalog No.: PC-23237Not For Human Use, Lab Use Only.

YD1130 is a potent, selective PRMT4 inhibitor with IC50 of <1 nM, 1000-fold selectivity for PRMT4 (IC50 < 0.5 nM) over a panel of 38 methyltransferases, including the other PRMTs.

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Biological Activity

YD1130 is a potent, selective PRMT4 inhibitor with IC50 of <1 nM, 1000-fold selectivity for PRMT4 (IC50 < 0.5 nM) over a panel of 38 methyltransferases, including the other PRMTs.

Physicochemical Properties

M.Wt	495.40
Formula	C19H23BrN6O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(3R,4R,5S)-2-(6-amino-9H-purin-9-yl)-5-(((2-((3-bromobenzyl)amino)ethyl)thio)methyl)tetrahydrofuran-3,4-diol

References

1. Deng Y, et al. J Med Chem. 2024 Oct 3. doi: 10.1021/acs.jmedchem.4c01041.

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YD1130

Biological Activity

Physicochemical Properties

References

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