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Chemical Structure : EML741
Catalog No.: PC-22921Not For Human Use, Lab Use Only.
EML741 is a potent, selective inhibitor of H3K9-specific methyltransferases G9a/G9a-like protein (G9a/GLP) with IC50 of 23 nM (G9a), KD of 1.13 uM in MST assays.
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EML741 is a potent, selective inhibitor of H3K9-specific methyltransferases G9a/G9a-like protein (G9a/GLP) with IC50 of 23 nM (G9a), KD of 1.13 uM in MST assays.
EML741 shows high selectivity against a panel of other epigenetic enzymes (KMT5A/SETD8, KDM4A/JMJD2A, PRMT1, PRMT3, KAT3B/p300).
EML741 (0.5 and 5 μM) induced a marked and both concentration- and time-dependent reduction in the dimethylation of lysine H3K9 in MCF-7 and MDA-MB-231 human breast adenocarcinoma cells.
| M.Wt | 523.77 | |
| Formula | C31H49N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ciro Milite, et al. J Med Chem. 2019 Mar 14;62(5):2666-2689.
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