Catalog No.: PC-22809Not For Human Use, Lab Use Only.
AM-9747 (AM9747) is a potent, selective and MTA cooperative PRMT5 inhibitor, inhibits symmetrical dimethyl arginine methylation (SDMA) levels in HCT116 MTAP-deleted cells with IC50 of 2 nM.
AM-9747 (AM9747) is a potent, selective and MTA cooperative PRMT5 inhibitor, inhibits symmetrical dimethyl arginine methylation (SDMA) levels in HCT116 MTAP-deleted cells with IC50 of 2 nM. AM-9747 selectively inhibited the proliferation of HCT116 MTAP-deleted cells (IC50 = 0.027 μM) compared to HCT116 MTAP-WT cells (IC50 = 0.63 μM). AM-9747 inhibited the proliferation of most MTAP-deleted cells, with minimal effects on MTAP-WT cells. AM-9747 induces DNA damage, as illustrated by increased phosphorylation of H2AX, and an arrest in the G2/M phase of the cell cycle in MTAP-deleted cells. AM-9747 selectively inhibits SDMA and tumor growth in HCT116 MTAP-deleted tumor xenografts, compared to HCT116 MTAP-WT xenografts.
