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Chemical Structure : MS167
Catalog No.: PC-23079Not For Human Use, Lab Use Only.
MS167 is a potent, selective and cell-active reversible PRMT6 inhibitor with IC50 of 28 nM.
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MS167 is a potent, selective and cell-active reversible PRMT6 inhibitor with IC50 of 28 nM.
MS167 does not inhibit other closely related PRMTs and was selective for PRMT6 over other methyltransferases.
MS167 potently and concentration-dependently reduces cellular levels of H3R2 asymmetric dimethylation (H3R2me2a, IC50=6.7 uM) against ectopically expressed PRMT6 in HEK293 cells.
MS167 is not cytotoxic in MCF-7, PNT2, and HEK293T cells.
| M.Wt | 300.41 | |
| Formula | C17H24N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shen Y, et al. J Med Chem. 2020 May 28;63(10):5477-5487.
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