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MS167

Chemical Structure : MS167

CAS No.: 2702280-87-1

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MS167 (MS-167)

Catalog No.: PC-23079Not For Human Use, Lab Use Only.

MS167 is a potent, selective and cell-active reversible PRMT6 inhibitor with IC50 of 28 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MS167 is a potent, selective and cell-active reversible PRMT6 inhibitor with IC50 of 28 nM.
MS167 does not inhibit other closely related PRMTs and was selective for PRMT6 over other methyltransferases.
MS167 potently and concentration-dependently reduces cellular levels of H3R2 asymmetric dimethylation (H3R2me2a, IC50=6.7 uM) against ectopically expressed PRMT6 in HEK293 cells.
MS167 is not cytotoxic in MCF-7, PNT2, and HEK293T cells.

Physicochemical Properties

M.Wt 300.41
Formula C17H24N4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3-(4-(((2-aminoethyl)(methyl)amino)methyl)-1H-pyrrol-3-yl)phenyl)propionamide

References

1. Shen Y, et al. J Med Chem. 2020 May 28;63(10):5477-5487.

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