Catalog No.: PC-22924Not For Human Use, Lab Use Only.
EML425 is a potent, selective, cell-permeable and reversible inhibitor of KAT3 histone acetyltransferases (CBP and p300) with IC50 of 1.1 and 2.9 uM respectively.
EML425 is a potent, selective, cell-permeable and reversible inhibitor of KAT3 histone acetyltransferases (CBP and p300) with IC50 of 1.1 and 2.9 uM respectively. EML425 is inactive against the enzymes GCN5 and PCAF. EML425 (50-100 uM) induced a marked and time-dependent reduction in the acetylation of lysine H4K5 and H3K9 in human leukemia U937 cells, a marked arrest in the G0/G1 phase. EML425 is more potent and selective than curcumin and anacardic acid, with a potency comparable to that of C646. EML425 is an invaluable chemical probe not only for mechanistic studies of p300-mediated lysine acetylation but also to further investigate the biological role of KAT3 enzymes.
