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Chemical Structure : EML425
CAS No.: 1675821-32-5
Catalog No.: PC-22924Not For Human Use, Lab Use Only.
EML425 is a potent, selective, cell-permeable and reversible inhibitor of KAT3 histone acetyltransferases (CBP and p300) with IC50 of 1.1 and 2.9 uM respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $158 | In stock | |
| 25 mg | $278 | In stock | |
| 50 mg | $488 | In stock | |
| 100 mg | Get quote |
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EML425 is a potent, selective, cell-permeable and reversible inhibitor of KAT3 histone acetyltransferases (CBP and p300) with IC50 of 1.1 and 2.9 uM respectively.
EML425 is inactive against the enzymes GCN5 and PCAF.
EML425 (50-100 uM) induced a marked and time-dependent reduction in the acetylation of lysine H4K5 and H3K9 in human leukemia U937 cells, a marked arrest in the G0/G1 phase.
EML425 is more potent and selective than curcumin and anacardic acid, with a potency comparable to that of C646.
EML425 is an invaluable chemical probe not only for mechanistic studies of p300-mediated lysine acetylation but also to further investigate the biological role of KAT3 enzymes.
| M.Wt | 440.50 | |
| Formula | C27H24N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-[(4-Hydroxy-2,6-dimethylphenyl)methylene]-1,3-bis(phenylmethyl)-2,4,6(1H,3H,5H)-pyrimidinetrione |
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1. Milite C, et al. J Med Chem. 2015 Mar 26;58(6):2779-98.
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