Chemical Structure : DCPT1061
CAS No.:
2289726-31-2
DCPT1061
(DCPT-1061)
Catalog No.: PC-23080Not For Human Use, Lab Use Only.
DCPT1061 is a selective inhibitor of type I PRMT subfamily members, potently inhibits PRMT1, PRMT6, and PRMT8, with less inhibitory effect on PRMT3, PRMT4, and PRMT5 or other epigenetic enzymes.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DCPT1061 is a selective inhibitor of type I PRMT subfamily members, potently inhibits PRMT1, PRMT6, and PRMT8, with less inhibitory effect on PRMT3, PRMT4, and PRMT5 or other epigenetic enzymes.
DCPT1061 significantly induced a dose-dependent inhibition of cell proliferation in ccRCC cell lines including 786-O, A498, ACHN, and Caki-1 (IC50=0.5-2.8 uM), induced G1 cycle arrest in ccRCC cells.
CPT1061 inhibited AKT and RB phosphorylation in Caki-1 cells.
Combinational treatment of DCPT1061 and sunitinib exhibited a striking anticancer effect in ccRCC.
Physicochemical Properties
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M.Wt
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339.26
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Formula
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C17H20Cl2N2O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N1-[[2-(2,3-Dichlorophenoxy)phenyl]methyl]-N1,N2-dimethyl-1,2-ethanediamine
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References
1. Wang J, et al. Theranostics. 2021 Mar 12;11(11):5387-5403.
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