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Chemical Structure : DCPT1061
Catalog No.: PC-23080Not For Human Use, Lab Use Only.
DCPT1061 is a selective inhibitor of type I PRMT subfamily members, potently inhibits PRMT1, PRMT6, and PRMT8, with less inhibitory effect on PRMT3, PRMT4, and PRMT5 or other epigenetic enzymes.
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DCPT1061 is a selective inhibitor of type I PRMT subfamily members, potently inhibits PRMT1, PRMT6, and PRMT8, with less inhibitory effect on PRMT3, PRMT4, and PRMT5 or other epigenetic enzymes.
DCPT1061 significantly induced a dose-dependent inhibition of cell proliferation in ccRCC cell lines including 786-O, A498, ACHN, and Caki-1 (IC50=0.5-2.8 uM), induced G1 cycle arrest in ccRCC cells.
CPT1061 inhibited AKT and RB phosphorylation in Caki-1 cells.
Combinational treatment of DCPT1061 and sunitinib exhibited a striking anticancer effect in ccRCC.
| M.Wt | 339.26 | |
| Formula | C17H20Cl2N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang J, et al. Theranostics. 2021 Mar 12;11(11):5387-5403.
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