SETD8 inhibitor C23 (RL5a)

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Chemical Structure : SETD8 inhibitor C23

Catalog No.: PC-23204Not For Human Use, Lab Use Only.

SETD8 inhibitor C23 (RL5a) is a novel chemical inhibitor of SETD8, inhibits H4K20 methylation, inhibits IR-induced 53BP1 foci.

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Biological Activity

SETD8 inhibitor C23 (RL5a) is a novel chemical inhibitor of SETD8, inhibits H4K20 methylation, inhibits IR-induced 53BP1 foci.
C23 does not affect the formation of foci for phosphorylated H2AX (γH2AX) in U2OS cells.
C23 phenocopies the impact of the SETD8 inhibitor UCN0379 in DNA replication.
C23 inhibits 53BP1 recruitment to DSBs and 53BP1-dependent repair activities.

Physicochemical Properties

M.Wt	281.36
Formula	C17H19N3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-(2-(furan-2-yl)quinolin-4-yl)-N2,N2-dimethylethane-1,2-diamine

References

1. Murga M, et al. Cell Death Dis. 2024 Sep 28;15(9):694.

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