| Cat. No. |
Product Name |
Information |
| PC-25913 |
DCG066
G9a inhibitor
|
DCG066 is a novel small molecule inhibitors of lysine methyltransferase G9a, inhibits G9a methyltransferase activity with IC50 of 6.5 uM. |
| PC-25711 |
Heterochromatin protein 1 inhibitor (R)-18
HP1 inhibitor
|
Heterochromatin protein 1 inhibitor (R)-18 is a small-molecule inhibitor of heterochromatin protein 1 (HP1), inhibits the HP1/H3K9me3 interaction with IC50 of 18.1 uM. |
| PC-25566 |
BMF-219
Menin inhibitor
|
BMF-219 (Icovamenib) is a potent, selective and covalent irreversible menin inhibitor, inhibits the growth of KRAS-mutated solid tumors with G12C, G12D, and G12V KRAS mutations. |
| PC-25565 |
RK-552
NSD2 inhibitor
|
RK-0080552 (RK-552) is a potent, specific small molecule NSD2 inhibitor with IC50 of 0.11 uM, weakly inhibits G9a (IC50=1.2 uM) and does not inhibit SET7/9. |
| PC-25506 |
LH168
WDR5 inhibitor
|
LH168 is a potent, exquisitely selective WDR5 chemical probe inhibitor with EC50 of 10 nM in cellulo target engagement NanoBRET assays, SPR KD of 1.9 nM. |
| PC-25447 |
DNMT2 inhibitor 16
DNMT2 inhibitor
|
DNMT2 inhibitor 16 is a potent, selective DNMT2 (TRDMT1) inhibitor with ITC KD of 3.04 uM, reduces m5C levels in MOLM-13 tRNA and synergizes with doxorubicin to impair cell viability, targeting a cryptic allosteric binding site. |
| PC-25322 |
IACS-17817
NSD2 inhibitor
|
IACS-17817 is a highly potent, selective and SAM-competitive inhibitor of NSD2 (MMSET, WHSC1) with IC50 of 19.0 nM, >50-fold selective over a KMT panel including NSD1, NSD3 and SETD2.
IACS-17817 inhibits NSD2 methylation of nucleosome substrates in vitro with IC50 of 19.0 nM. |
| PC-25273 |
UNC0646
G9a inhibitor
|
UNC0646 (UNC 0646) is a potent, selective and cell-active inhibitor of G9a methyltransferase with IC50 of 6 nM in SAHH-coupled assays, reduces H3K9me2 levels in MDA-MB-231 cells with IC50 of 26 nM. |
| PC-25272 |
UNC0631
G9a inhibitor
|
UNC0631 (UNC 0631) is a potent, selective and cell-active inhibitor of G9a methyltransferase with IC50 of 4 nM in SAHH-coupled assays, reduces H3K9me2 levels in MDA-MB-231 cells with IC50 of 25 nM. |
| PC-24896 |
KMT9 inhibitor 7b
KMT9 inhibitor
|
KMT9 inhibitor 7b is a potent and selective lysine methyltransferase 9 (KMT9) inhibitor with Kd of 10 nM. |
| PC-24895 |
KMT9 inhibitor 8
KMT9 inhibitor
|
KMT9 inhibitor 8 is the ethyl ester prodrug of KMT9 inhibitor 7b, a potent and selective lysine methyltransferase 9 (KMT9) inhibitor with Kd of 10 nM. |
| PC-24527 |
HH2853
EZH1/2 inhibitor
|
HH2853 is a novel potent dual EZH1/2 inhibitor that effectively inhibit the catalytic activity of wild-type EZH2 and mutated forms (A677G, Y641F, Y641N, and Y641C) with IC50 of 3.75, 2.21, 2.65, and 2.62 nM respectively, synchronously suppresses EZH1 activity with IC50 of 9.26 nM. |
