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Chemical Structure : EPZ005687
CAS No.: 1396772-26-1
Catalog No.: PC-21951Not For Human Use, Lab Use Only.
EPZ005687 is a potent, selective and SAM-competitive inhibitor of EZH2 with Ki of 24 nM, 50-fold selectivity over EZH1 and 500-fold selectivity against 15 other protein methyltransferases.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote |
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EPZ005687 is a potent, selective and SAM-competitive inhibitor of EZH2 with Ki of 24 nM, 50-fold selectivity over EZH1 and 500-fold selectivity against 15 other protein methyltransferases.
EPZ005687 reduces H3K27 methylation in various lymphoma cells.
EPZ005687 suppresses cell proliferation and migration in sarcoma cell lines.
| M.Wt | 539.68 | |
| Formula | C32H37N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-Cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide |
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1. Knutson SK, et al. Nat Chem Biol. 2012 Nov;8(11):890-6.
2. Shen JK, et al. Sci Rep. 2016 Apr 29;6:25239.
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