Catalog No.: PC-21951Not For Human Use, Lab Use Only.
EPZ005687 is a potent, selective and SAM-competitive inhibitor of EZH2 with Ki of 24 nM, 50-fold selectivity over EZH1 and 500-fold selectivity against 15 other protein methyltransferases.
EPZ005687 is a potent, selective and SAM-competitive inhibitor of EZH2 with Ki of 24 nM, 50-fold selectivity over EZH1 and 500-fold selectivity against 15 other protein methyltransferases. EPZ005687 reduces H3K27 methylation in various lymphoma cells. EPZ005687 suppresses cell proliferation and migration in sarcoma cell lines.
