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Chemical Structure : WDR5 WIN site inhibitor C6 TFA
Catalog No.: PC-22311Not For Human Use, Lab Use Only.
WDR5 inhibitor C6 TFA is a highly potent WDR5 WIN site inhibitor with Kd of 0.1 nM.
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WDR5 inhibitor C6 TFA is a highly potent WDR5 WIN site inhibitor with Kd of 0.1 nM.
WDR5 inhibitor C6 inhibits cell lines and primary transformed cells carrying MLL1 rearrangements (MV4:11, IC50=3.2 uM), induces apoptosis and kills cells in a p53-dependent manner.
WDR5 inhibitor C6 rapidly displace WDR5 from chromatin and decrease the expression of associated genes, causing translational inhibition, nucleolar stress, and p53 induction.
| M.Wt | 612.41 | |
| Formula | C27H23Cl2F4N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Aho ER, et al. Cell Rep. 2019 Mar 12;26(11):2916-2928.e13.
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