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WDR5 WIN site inhibitor C6 TFA

Chemical Structure : WDR5 WIN site inhibitor C6 TFA

CAS No.: 2749300-35-2

WDR5 WIN site inhibitor C6 TFA

Catalog No.: PC-22311Not For Human Use, Lab Use Only.

WDR5 inhibitor C6 TFA is a highly potent WDR5 WIN site inhibitor with Kd of 0.1 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

WDR5 inhibitor C6 TFA is a highly potent WDR5 WIN site inhibitor with Kd of 0.1 nM.
WDR5 inhibitor C6 inhibits cell lines and primary transformed cells carrying MLL1 rearrangements (MV4:11, IC50=3.2 uM), induces apoptosis and kills cells in a p53-dependent manner.
WDR5 inhibitor C6 rapidly displace WDR5 from chromatin and decrease the expression of associated genes, causing translational inhibition, nucleolar stress, and p53 induction.

Physicochemical Properties

M.Wt 612.41
Formula C27H23Cl2F4N5O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Benzamide, N-[(3,4-dichlorophenyl)methyl]-3-[(2,3-dihydro-2-imino-3-methyl-1H-imidazol-1-yl)methyl]-5-(6-fluoro-2-methyl-3-pyridinyl)-, 2,2,2-trifluoroacetate (1:1)

References

1. Aho ER, et al. Cell Rep. 2019 Mar 12;26(11):2916-2928.e13.

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