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YTHDC1 inhibitor 40

Chemical Structure : YTHDC1 inhibitor 40

CAS No.: 2995344-53-9

YTHDC1 inhibitor 40

Catalog No.: PC-22428Not For Human Use, Lab Use Only.

YTHDC1 inhibitor 40 is a potent, selective m6A reader YTHDC1 inhibitor with ITC Kd of 49 nM, HTRF IC50 of 0.35 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

YTHDC1 inhibitor 40 is a potent, selective m6A reader YTHDC1 inhibitor with ITC Kd of 49 nM, HTRF IC50 of 0.35 uM.
YTHDC1 inhibitor 40 exhibits antiproliferative activity against THP-1 (GI50 = 3.2 μM), MOLM-13 (5.6 μM) and NOMO-1 (8.2 μM), respectively.
YTHDC1 inhibitor 40 displays IC50 values of 89, 60, and 83 μM against YTHDF1, YTHDF2, and YTHDF3, respectively, indicating a 200-fold selectivity.
YTHDC1 inhibitor 40 does not display significant inhibition of a panel of 58 protein kinases.
YTHDC1 inhibitor 40 (2.5-10 uM) induces apoptosis in THP-1 cell line after 24 h treatment.
YTHDC1 inhibitor 40 is a tool compound for studying the role of YTHDC1 in AML.

Physicochemical Properties

M.Wt 308.17
Formula C13H11Cl2N5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-chloro-3-(3-chlorobenzyl)-N-methyl-2H-pyrazolo[4,3-d]pyrimidin-7-amine

References

1. František Zálešák, et al. J Med Chem. 2024 May 24. doi: 10.1021/acs.jmedchem.4c00599.

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