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Chemical Structure : YTHDC1 inhibitor 40
Catalog No.: PC-22428Not For Human Use, Lab Use Only.
YTHDC1 inhibitor 40 is a potent, selective m6A reader YTHDC1 inhibitor with ITC Kd of 49 nM, HTRF IC50 of 0.35 uM.
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YTHDC1 inhibitor 40 is a potent, selective m6A reader YTHDC1 inhibitor with ITC Kd of 49 nM, HTRF IC50 of 0.35 uM.
YTHDC1 inhibitor 40 exhibits antiproliferative activity against THP-1 (GI50 = 3.2 μM), MOLM-13 (5.6 μM) and NOMO-1 (8.2 μM), respectively.
YTHDC1 inhibitor 40 displays IC50 values of 89, 60, and 83 μM against YTHDF1, YTHDF2, and YTHDF3, respectively, indicating a 200-fold selectivity.
YTHDC1 inhibitor 40 does not display significant inhibition of a panel of 58 protein kinases.
YTHDC1 inhibitor 40 (2.5-10 uM) induces apoptosis in THP-1 cell line after 24 h treatment.
YTHDC1 inhibitor 40 is a tool compound for studying the role of YTHDC1 in AML.
| M.Wt | 308.17 | |
| Formula | C13H11Cl2N5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. František Zálešák, et al. J Med Chem. 2024 May 24. doi: 10.1021/acs.jmedchem.4c00599.
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