YTHDC1 inhibitor 40 (YTHDC1-IN-1) is a potent, selective m6A reader YTHDC1 inhibitor with ITC Kd of 49 nM, HTRF IC50 of 0.35 uM.
YTHDC1 inhibitor 40 exhibits antiproliferative activity against THP-1 (GI50 = 3.2 μM), MOLM-13 (5.6 μM) and NOMO-1 (8.2 μM), respectively.
YTHDC1 inhibitor 40 displays IC50 values of 89, 60, and 83 μM against YTHDF1, YTHDF2, and YTHDF3, respectively, indicating a 200-fold selectivity.
YTHDC1 inhibitor 40 does not display significant inhibition of a panel of 58 protein kinases.
YTHDC1 inhibitor 40 (2.5-10 uM) induces apoptosis in THP-1 cell line after 24 h treatment.
YTHDC1 inhibitor 40 is a tool compound for studying the role of YTHDC1 in AML.
