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Chemical Structure : AZ39
Catalog No.: PC-22291Not For Human Use, Lab Use Only.
AZ39 is a potent, selective inhibitor of protein lysine methyltransferase SMYD2 with IC50 of 28 nM, inhibits SMYD2 mediated methylation of monomethyl p53 peptide in U2OS cells with IC50 of 280 nM.
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AZ39 is a potent, selective inhibitor of protein lysine methyltransferase SMYD2 with IC50 of 28 nM, inhibits SMYD2 mediated methylation of monomethyl p53 peptide in U2OS cells with IC50 of 280 nM.
AZ39 is selective for SMYD2 but do possess limited activity against DOT1L, in a focused panel of KMTs including EZH2, NSD1, G9a SMYD2, and DOT1L.
| M.Wt | 560.75 | |
| Formula | C35H40N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Scott D. Cowen, et al. J. Med. Chem. 2016, 59, 24, 11079–11097.
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