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AZ39

Chemical Structure : AZ39

CAS No.: 2043321-39-5

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AZ39 (SMYD2 inhibitor AZ39, AZ-39)

Catalog No.: PC-22291Not For Human Use, Lab Use Only.

AZ39 is a potent, selective inhibitor of protein lysine methyltransferase SMYD2 with IC50 of 28 nM, inhibits SMYD2 mediated methylation of monomethyl p53 peptide in U2OS cells with IC50 of 280 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AZ39 is a potent, selective inhibitor of protein lysine methyltransferase SMYD2 with IC50 of 28 nM, inhibits SMYD2 mediated methylation of monomethyl p53 peptide in U2OS cells with IC50 of 280 nM.
    AZ39 is selective for SMYD2 but do possess limited activity against DOT1L, in a focused panel of KMTs including EZH2, NSD1, G9a SMYD2, and DOT1L.

    Physicochemical Properties

    M.Wt 560.75
    Formula C35H40N6O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2'-(4-(2-(1H-Indol-3-yl)ethyl)piperazin-1-yl)-5-cyano-N-(3-(pyrrolidin-1-yl)propyl)-[1,1'-biphenyl]-3-carboxamide

    References

    1. Scott D. Cowen, et al. J. Med. Chem. 2016, 59, 24, 11079–11097.

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