AZ39 | SMYD2 inhibitor | Probechem Biochemicals

Chemical Structure : AZ39

AZ39 (SMYD2 inhibitor AZ39, AZ-39)

Catalog No.: PC-22291Not For Human Use, Lab Use Only.

AZ39 is a potent, selective inhibitor of protein lysine methyltransferase SMYD2 with IC50 of 28 nM, inhibits SMYD2 mediated methylation of monomethyl p53 peptide in U2OS cells with IC50 of 280 nM.

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Biological Activity

AZ39 is a potent, selective inhibitor of protein lysine methyltransferase SMYD2 with IC50 of 28 nM, inhibits SMYD2 mediated methylation of monomethyl p53 peptide in U2OS cells with IC50 of 280 nM.
AZ39 is selective for SMYD2 but do possess limited activity against DOT1L, in a focused panel of KMTs including EZH2, NSD1, G9a SMYD2, and DOT1L.

Physicochemical Properties

M.Wt	560.75
Formula	C35H40N6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2'-(4-(2-(1H-Indol-3-yl)ethyl)piperazin-1-yl)-5-cyano-N-(3-(pyrrolidin-1-yl)propyl)-[1,1'-biphenyl]-3-carboxamide

References

1. Scott D. Cowen, et al. J. Med. Chem. 2016, 59, 24, 11079–11097.

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AZ39 (SMYD2 inhibitor AZ39, AZ-39)

Biological Activity

Physicochemical Properties

References

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