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Chemical Structure : UNC1999
CAS No.: 1431612-23-5
Catalog No.: PC-21940Not For Human Use, Lab Use Only.
UNC1999 is a potent, selectice SAM-competitive and orally bioavailable inhibitor of EZH2/EZH1 with IC50 of <10 nM/45 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | $368 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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UNC1999 is a potent, selectice SAM-competitive and orally bioavailable inhibitor of EZH2/EZH1 with IC50 of <10 nM/45 nM, respectively.
UNC1999 is highly selective for EZH2 and EZH1 over a broad range of epigenetic and non-epigenetic targets.
UNC1999 potently reduces H3K27me3 levels in cells and selectively killed diffused large B cell lymphoma cell lines harboring the EZH2(Y641N) mutant.
UNC1999 prolongs survival of a well-defined murine leukemia model bearing MLL-AF9.
| M.Wt | 569.75 | |
| Formula | C33H43N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-Isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide |
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1. Grinshtein N, et al. Oncotarget. 2016 Sep 13;7(37):59360-59376.
2. Xu B, et al. Blood. 2015 Jan 8;125(2):346-57.
3. Konze KD, et al. ACS Chem Biol. 2013;8(6):1324-34.
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