NSD2-PWWP1 inhibitor 34

Chemical Structure : NSD2-PWWP1 inhibitor 34

Catalog No.: PC-22295Not For Human Use, Lab Use Only.

NSD2-PWWP1 inhibitor 34 is a potent, selective NSD2-PWWP1 binder / inhibitor with pIC50 of 8.2, pKd of 8.6.

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Biological Activity

NSD2-PWWP1 inhibitor 34 is a potent, selective NSD2-PWWP1 binder / inhibitor with pIC50 of 8.2, pKd of 8.6.
NSD2-PWWP1 inhibitor 34 shows pIC50 of 8.4 in NSD2 NanoBRET assay using U2OS cell lines.

Physicochemical Properties

M.Wt	417.51
Formula	C25H27N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(5-Methyl-3-(2-methyl-5-(piperidin-1-ylmethyl)phenyl)isoxazol-4-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one

References

1. Carlino L, et al. J Med Chem. 2024 May 15. doi: 10.1021/acs.jmedchem.4c00215.

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