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Chemical Structure : PRMT9 inhibitor LD2
CAS No.: 1134334-55-6
Catalog No.: PC-22354Not For Human Use, Lab Use Only.
PRMT9 inhibitor LD2 is a specific small molecule PRMT9 inhibitor, inhibits PABPC1 R493 methylation level with IC50 of 0.9 uM in in Molm13s, sparing other PRMTs.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $288 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $588 | In stock | |
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| 100 mg | Get quote |
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PRMT9 inhibitor LD2 is a specific small molecule PRMT9 inhibitor, inhibits PABPC1 R493 methylation level with IC50 of 0.9 uM in in Molm13s, sparing other PRMTs.
LD2 binds PRMT9 (−7.15 kcal mol−1) with greater affinity than the other PRMTs tested.
LD2 treatment preferentially inhibited the viability of cancer cells and their protein synthesis.
LD2 treatment (2.5 uM) expanded the number of IFN-γ-expressing T cells relative to vehicle controls in AML mononuclear cells (MNCs), without effect on T cell viability.
LD2 synergizes with anti-programmed cell death protein 1 in eradicating AML.
| M.Wt | 247.68 | |
| Formula | C12H10ClN3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-chloro-8-methoxy-5-methyl-5H-pyrimido[5,4-b]indole |
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1. Dong H, et al. Nat Cancer. 2024 Apr;5(4):601-624.
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