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PRMT9 inhibitor LD2

Chemical Structure : PRMT9 inhibitor LD2

CAS No.: 1134334-55-6

PRMT9 inhibitor LD2

Catalog No.: PC-22354Not For Human Use, Lab Use Only.

PRMT9 inhibitor LD2 is a specific small molecule PRMT9 inhibitor, inhibits PABPC1 R493 methylation level with IC50 of 0.9 uM in in Molm13s, sparing other PRMTs.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PRMT9 inhibitor LD2 is a specific small molecule PRMT9 inhibitor, inhibits PABPC1 R493 methylation level with IC50 of 0.9 uM in in Molm13s, sparing other PRMTs.
LD2 binds PRMT9 (−7.15 kcal mol−1) with greater affinity than the other PRMTs tested.
LD2 treatment preferentially inhibited the viability of cancer cells and their protein synthesis.
LD2 treatment (2.5 uM) expanded the number of IFN-γ-expressing T cells relative to vehicle controls in AML mononuclear cells (MNCs), without effect on T cell viability.
LD2 synergizes with anti-programmed cell death protein 1 in eradicating AML.

Physicochemical Properties

M.Wt 247.68
Formula C12H10ClN3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-chloro-8-methoxy-5-methyl-5H-pyrimido[5,4-b]indole

References

1. Dong H, et al. Nat Cancer. 2024 Apr;5(4):601-624.

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