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MM-102 trifluoroacetate

Chemical Structure : MM-102 trifluoroacetate

CAS No.: 1883545-52-5

MM-102 trifluoroacetate (MM-102 TFA)

Catalog No.: PC-42923Not For Human Use, Lab Use Only.

MM-102 trifluoroacetate is a high-affinity, small-molecule peptidomimetic inhibitor of MLL1/WDR5 protein-protein interaction with Ki of 2.4 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MM-102 trifluoroacetate is a high-affinity, small-molecule peptidomimetic inhibitor of MLL1/WDR5 protein-protein interaction with Ki of 2.4 nM.
MM-102 effectively decreases the expression of HoxA9 and Meis-1.
MM-102 specifically inhibits cell growth and induces apoptosis in leukemia cells harboring MLL1 fusion proteins.

Physicochemical Properties

M.Wt 783.8282
Formula C37H50F5N7O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-N-(bis(4-fluorophenyl)methyl)-1-(2-(2-ethyl-2-isobutyramidobutanamido)-5-guanidinopentanamido)cyclopentanecarboxamide 2,2,2-trifluoroacetate

References

1. Karatas H, et al. J Am Chem Soc. 2013 Jan 16;135(2):669-82.

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