Catalog No.: PC-45576Not For Human Use, Lab Use Only.
AMI-1 (Arginine methyltransferase inhibitor 1) is a specific inhibitor of PRMTs (protein arginine methyltransferases), but not lysine methyltransferases.
AMI-1 (Arginine methyltransferase inhibitor 1) is a specific inhibitor of PRMTs (protein arginine methyltransferases), but not lysine methyltransferases.
AMI-1 inhibits PRMT1 and Hmt1p with IC50s of 8.81 uM and 3.03 uM respectively.
AMI-1 increases the ratio of Bax/Bcl-2, and leads to apoptosis and loss of migratory activity in several HCC cells.
AMI-1 decreases the expression levels of H4R3me2s; strongly inhibits HCC growth in vivo.
Physicochemical Properties
M.Wt
548.4534
Formula
C21H14N2Na2O9S2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: ≥ 46 mg/mL
Chemical Name/SMILES
2-Naphthalenesulfonic acid, 7,7'-(carbonyldiimino)bis[4-hydroxy-, sodium salt (1:2)
References
1. Cheng D, et al. J Biol Chem. 2004 Jun 4;279(23):23892-9.
2. Zhang B, et al. Oncotarget. 2015 Sep 8;6(26):22799-811.
3. Zhang B, et al. J Transl Med. 2015 Nov 5;13:349.
