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Chemical Structure : AMI-1
CAS No.: 20324-87-2
Catalog No.: PC-45576Not For Human Use, Lab Use Only.
AMI-1 (Arginine methyltransferase inhibitor 1) is a specific inhibitor of PRMTs (protein arginine methyltransferases), but not lysine methyltransferases.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 100 mg | $498 | In stock | |
| 250 mg | $798 | In stock | |
| 1 g | Get quote |
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AMI-1 (Arginine methyltransferase inhibitor 1) is a specific inhibitor of PRMTs (protein arginine methyltransferases), but not lysine methyltransferases.
AMI-1 inhibits PRMT1 and Hmt1p with IC50s of 8.81 uM and 3.03 uM respectively.
AMI-1 increases the ratio of Bax/Bcl-2, and leads to apoptosis and loss of migratory activity in several HCC cells.
AMI-1 decreases the expression levels of H4R3me2s; strongly inhibits HCC growth in vivo.
| M.Wt | 548.4534 | |
| Formula | C21H14N2Na2O9S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 46 mg/mL |
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| Chemical Name/SMILES |
2-Naphthalenesulfonic acid, 7,7'-(carbonyldiimino)bis[4-hydroxy-, sodium salt (1:2) |
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1. Cheng D, et al. J Biol Chem. 2004 Jun 4;279(23):23892-9.
2. Zhang B, et al. Oncotarget. 2015 Sep 8;6(26):22799-811.
3. Zhang B, et al. J Transl Med. 2015 Nov 5;13:349.
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