MS049 | PRMT4/6 inhibitor | Probechem Biochemicals

Chemical Structure : MS049

CAS No.: 1502816-23-0

MS049 (MS-049)

Catalog No.: PC-42113Not For Human Use, Lab Use Only.

MS049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC50 of 34±10 nM and 43±7 nM, respectively.

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10 mg	$88	In stock
25 mg	$148	In stock
50 mg	$238	In stock
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Biological Activity

MS049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC50 of 34±10 nM and 43±7 nM, respectively.
MS049 displays >30-fold and >300-fold selectivity over PRMT8 and PRMT1/3, does not inhibits PKMTs, DNMTases, RNA methyltransferases.
MS049 reduces the H3R2me2a mark in HEK293 cells with IC50 of 0.97 uM.

Physicochemical Properties

M.Wt	248.3639
Formula	C15H24N2O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: ≥ 31 mg/mL
Chemical Name/SMILES	1-Piperidineethanamine, N-methyl-4-(phenylmethoxy)-

References

1. Shen Y, et al. J Med Chem. 2016 Oct 13;59(19):9124-9139.

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MS049 (MS-049)

Biological Activity

Physicochemical Properties

References

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