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Chemical Structure : EPZ-011989 trifluoroacetate
CAS No.: 1598383-41-5
Catalog No.: PC-45115Not For Human Use, Lab Use Only.
EPZ-011989 trifluoroacetate is a potent, selective, orally bioavailable inhibitor of EZH2 with Ki of < 3 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $288 | In stock | |
| 100 mg | Get quote |
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EPZ-011989 trifluoroacetate is a potent, selective, orally bioavailable inhibitor of EZH2 with Ki of < 3 nM.
EPZ-011989 equipotently inhibits mutant and wild-type EZH2, displays >15-fold selectivity over EZH1 and >3000-fold selectivity over other HMTs.
EPZ-011989 demonstrates significant tumor growth inhibition in a mouse xenograft model of human B cell lymphoma.
| M.Wt | 719.8339 | |
| Formula | C37H52F3N5O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 34 mg/mL |
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| Chemical Name/SMILES |
Benzamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-[ethyl[trans-4-[(2-methoxyethyl)methylamino]cyclohexyl]amino]-2-methyl-5-[3-(4-morpholinyl)-1-propyn-1-yl]-, 2,2,2-trifluoroacetate (1:x) |
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1. Campbell JE, et al. ACS Med Chem Lett. 2015 Mar 4;6(5):491-5.
2. Gardner EE, et al. Cancer Cell. 2017 Feb 13;31(2):286-299.
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