Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : OICR-9429
CAS No.: 1801787-56-3
Catalog No.: PC-45120Not For Human Use, Lab Use Only.
OICR-9429 is a potent, selective, small-molecule antagonist of WDR5-MLL interaction that binds to WDR5 with Kd of 93±28 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $168 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
OICR-9429 is a potent, selective, small-molecule antagonist of WDR5-MLL interaction that binds to WDR5 with Kd of 93±28 nM.
OICR-9429 competitively disrupts the interaction with a high-affinity Wdr5-INteracting (WIN) peptide of MLL (Kdisp=64 nM).
OICR-9429 shows no significant binding or inhibition for 22 human methyltransferases, 9 different WD40- and histone reader domains.
OICR-9429 selectively inhibits proliferation and induces differentiation in p30-expressing human AML cells.
| M.Wt | 555.5913 | |
| Formula | C29H32F3N5O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
DMSO: ≥ 32 mg/mL |
|
| Chemical Name/SMILES |
3-Pyridinecarboxamide, 1,6-dihydro-N-[4-(4-methyl-1-piperazinyl)-3'-(4-morpholinylmethyl)[1,1'-biphenyl]-3-yl]-6-oxo-4-(trifluoromethyl)- |
|
1. Grebien F, et al. Nat Chem Biol. 2015 Aug;11(8):571-578.
2. Getlik M, et al. J Med Chem. 2016 Mar 24;59(6):2478-96.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
