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BAY-155

Chemical Structure : BAY-155

CAS No.: 2163769-52-4

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BAY-155 (BAY155)

Catalog No.: PC-38218Not For Human Use, Lab Use Only.

BAY-155 (BAY155) is a novel, potent and selective menin-MLL inhibitor with binding IC50 of 8 nM, 10-fold better compared to that of MI-503.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BAY-155 (BAY155) is a novel, potent and selective menin-MLL inhibitor with binding IC50 of 8 nM, 10-fold better compared to that of MI-503.
    BAY-155 demonstrated a significantly enhanced selectivity profile compared to MI-503 in a panel of assays covering numerous safety pharmacology-relevant targets including GPCRs, ion channels and transporters.
    BAY-155 shows anti-proliferative activity in a large cell line panel, exhibits specific therapeutic activityin AML/ALL models.

    Physicochemical Properties

    M.Wt 567.635
    Formula C28H28F3N7OS
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(2-cyano-4-methyl-5-((2-(6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)-2,7-diazaspiro[3.5]nonan-7-yl)methyl)-1H-indol-1-yl)acetamide

    References

    1. Krzysztof Brzezinka, et al. Cancers (Basel). 2020 Jan 14;12(1):201.

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