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Chemical Structure : WDR5 WIN site inhibitor C6
CAS No.: 2407457-36-5
Catalog No.: PC-36119Not For Human Use, Lab Use Only.
WDR5 inhibitor C6 (WDR5-IN-4) is a highly potent WDR5 WIN site inhibitor with Kd of 0.1 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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WDR5 inhibitor C6 (WDR5-IN-4) is a highly potent WDR5 WIN site inhibitor with Kd of 0.1 nM.
WDR5 inhibitor C6 inhibits cell lines and primary transformed cells carrying MLL1 rearrangements (MV4:11, IC50=3.2 uM), induces apoptosis and kills cells in a p53-dependent manner.
WDR5 inhibitor C6 rapidly displace WDR5 from chromatin and decrease the expression of associated genes, causing translational inhibition, nucleolar stress, and p53 induction.
| M.Wt | 498.383 | |
| Formula | C25H22Cl2FN5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(3,4-dichlorobenzyl)-3-(6-fluoro-2-methylpyridin-3-yl)-5-((2-imino-3-methyl-2,3-dihydro-1H-imidazol-1-yl)methyl)benzamide |
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1. Aho ER, et al. Cell Rep. 2019 Mar 12;26(11):2916-2928.e13.
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