You are here:Home-Chemical Inhibitors & Agonists-Epigenetics-Histone Methyltransferase (HMTase)-WDR5 WIN site inhibitor C6
WDR5 WIN site inhibitor C6

Chemical Structure : WDR5 WIN site inhibitor C6

CAS No.: 2407457-36-5

WDR5 WIN site inhibitor C6 (WDR5 inhibitor)

Catalog No.: PC-36119Not For Human Use, Lab Use Only.

WDR5 inhibitor C6 is a highly potent WDR5 WIN site inhibitor with Kd of 0.1 nM.

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    WDR5 inhibitor C6 is a highly potent WDR5 WIN site inhibitor with Kd of 0.1 nM.
    WDR5 inhibitor C6 inhibits cell lines and primary transformed cells carrying MLL1 rearrangements (MV4:11, IC50=3.2 uM), induces apoptosis and kills cells in a p53-dependent manner.
    WDR5 inhibitor C6 rapidly displace WDR5 from chromatin and decrease the expression of associated genes, causing translational inhibition, nucleolar stress, and p53 induction.

    Physicochemical Properties

    M.Wt 498.383
    Formula C25H22Cl2FN5O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-(3,4-dichlorobenzyl)-3-(6-fluoro-2-methylpyridin-3-yl)-5-((2-imino-3-methyl-2,3-dihydro-1H-imidazol-1-yl)methyl)benzamide

    References

    1. Aho ER, et al. Cell Rep. 2019 Mar 12;26(11):2916-2928.e13.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: