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Chemical Structure : WDR5 WIN site inhibitor C3
Catalog No.: PC-36120Not For Human Use, Lab Use Only.
WDR5 WIN site inhibitor C3 is a potent, specific WIN (WDR5 interaction) site inhibitor of WDR5 with Kd of 1.3 nM.
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WDR5 WIN site inhibitor C3 is a potent, specific WIN (WDR5 interaction) site inhibitor of WDR5 with Kd of 1.3 nM; inhibits leukemia cell lines in vitro (MV4:11 cell GI50=6.67 uM), rapidly displace WDR5 from chromatin and decrease the expression of associated genes, causing translational inhibition, nucleolar stress, and p53 induction.
| M.Wt | 386.427 | |
| Formula | C20H23FN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Aho ER, et al. Cell Rep. 2019 Mar 12;26(11):2916-2928.e13.
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