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WDR5 WIN site inhibitor C3

Chemical Structure : WDR5 WIN site inhibitor C3

CAS No.: 2407457-34-3

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WDR5 WIN site inhibitor C3 (WDR5 WIN-IN-C3)

Catalog No.: PC-36120Not For Human Use, Lab Use Only.

WDR5 WIN site inhibitor C3 is a potent, specific WIN (WDR5 interaction) site inhibitor of WDR5 with Kd of 1.3 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    WDR5 WIN site inhibitor C3 is a potent, specific WIN (WDR5 interaction) site inhibitor of WDR5 with Kd of 1.3 nM.
    WDR5 WIN site inhibitor C3 inhibits leukemia cell lines in vitro (MV4:11 cell GI50=6.67 uM).
    WDR5 WIN site inhibitor C3 rapidly displace WDR5 from chromatin and decrease the expression of associated genes, causing translational inhibition, nucleolar stress, and p53 induction.

    Physicochemical Properties

    M.Wt 386.427
    Formula C20H23FN4O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(((4,5-dihydro-1H-imidazol-2-yl)amino)methyl)-N-(3,5-dimethoxybenzyl)-4-fluorobenzamide

    References

    1. Aho ER, et al. Cell Rep. 2019 Mar 12;26(11):2916-2928.e13.

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