Chemical Structure : SHIN1
CAS No.:
2146095-85-2
SHIN1
(RZ-2994, RZ 2994)
Catalog No. : PC-38151Not For Human Use, Lab Use Only.
SHIN1 (RZ-2994, RZ 2994) is a folate-competitive, cell-permeable inhibitor of human SHMT1/2 with biochemical IC50 of 5/13 nM.
Packing Price Stock Quantity 5 mg $158 In stock 0 1 2 3 4 5 10 mg $248 In stock 0 1 2 3 4 5 25 mg $428 In stock 0 1 2 3 4 5 50 mg $728 In stock 0 1 2 3 4 5 100 mg Get quote 0 1 2 3 4 5 200 mg Get quote 0 1 2 3 4 5 1 g Get quote 0 1 2 3 4 5
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-3815101
Biological Activity
SHIN1 (RZ-2994, RZ 2994) is a folate-competitive, cell-permeable inhibitor of human SHMT1/2 with biochemical IC50 of 5/13 nM.
Physicochemical Properties
M.Wt
400.482
Formula
C24H24N4O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
100 mM in DMSO (40.1 mg/mL)
Chemical Name/SMILES
6-Amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1'-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)pyrano[2,3-c]pyrazole-5-carbonitrile
References
1. Juan C García-Cañaveras, et al. Leukemia.
2. Gregory S Ducker, et al. Proc Natl Acad Sci U S A.
3. Pikman Y, et al. Leukemia.
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