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MU1656

Chemical Structure : MU1656

CAS No.: 2768008-84-8

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MU1656 (MU 1656)

Catalog No.: PC-38010Not For Human Use, Lab Use Only.

MU1656 (MU 1656 ) is a potent, highly selective inhibitor of histone methyltransferase DOT1L with IC50 of 2 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MU1656 (MU 1656 ) is a potent, highly selective inhibitor of histone methyltransferase DOT1L with IC50 of 2 nM.
    MU1656 displays highly selectively against a panel of 37 methyltransferases.
    MU1656 is more metabolically stable and significantly less toxic in vivo than pinometostat.

    Physicochemical Properties

    M.Wt 559.759
    Formula C32H45N7O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (1R,2S,3S,5R)-3-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)cyclopentane-1,2-diol

    References

    1. Khirsariya P, et al. J Med Chem. 2022 Apr 14;65(7):5701-5723.

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