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SGC8158

Chemical Structure : SGC8158

CAS No.:

SGC8158 (SGC-8158, SGC 8158)

Catalog No.: PC-72395Not For Human Use, Lab Use Only.

SGC8158 (SGC-8158) is a potent, selective, and SAM-competitive inhibitor of PRMT7 with IC50 of <2.5 nM, the active component of it's cell permeable prodrug SGC3027.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SGC8158 (SGC-8158) is a potent, selective, and SAM-competitive inhibitor of PRMT7 with IC50 of <2.5 nM, the active component of it's cell permeable prodrug SGC3027.

    Physicochemical Properties

    M.Wt 555.094
    Formula C27H31ClN6O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-(((4-(((4'-chloro-[1,1'-biphenyl]-3-yl)methyl)amino)butyl)thio)methyl)tetrahydrofuran-3,4-diol

    References

    1. Szewczyk MM, et al. Nat Commun. 2020 May 14;11(1):2396.

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